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CPADS: a web tool for comprehensive pancancer analysis of drug sensitivity

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Kexin[1,2] * ; Yang Hong[1] * ; Lin Anqi[1] * ; Xie Jiayi[1] * ; Wang Haitao[3] * ; Zhou Jianguo[4] * ; Carr Shamus R[3] ; Liu Zaoqu[5,6] ; Li Xiaohua[7] ; Zhang Jian[1,*1] ; Cheng Quan[8,9,*2] ; Schrump David S[3,*3] ; Luo Peng[1,*4] ; Wei Ting[1,*5] ;
机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Avenue Zhong, Guangzhou, Guangdong, China. [2]The Second School of Clinical Medicine, Southern Medical University, No. 253, Industrial Avenue Zhong, Guangzhou, Guangdong, China. [3]Thoracic Surgery Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, Maryland 20850, United States. [4]Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Intersection of Xinlong Avenue and Xinpu Avenue, Honghuagang District, Zunyi City 563000, China. [5]State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, No. 33, Life Park Road, Zhongguancun, Changping District, Beijing 102206, China. [6]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China. [7]Department of Respiratory and Critical Care Medicine, Sixth People's Hospital of Chengdu, No. 16, Jianjian South Street, Chengdu, Sichuan Province 610051, China. [8]Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, China. [9]Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, China.
出处：
DOI： 10.1093/bib/bbae237
ISSN：

关键词： drugsensitivity CPADS pancancer geneperturbation Shiny webtools

摘要：
Drug therapy is vital in cancer treatment. Accurate analysis of drug sensitivity for specific cancers can guide healthcare professionals in prescribing drugs, leading to improved patient survival and quality of life. However, there is a lack of web-based tools that offer comprehensive visualization and analysis of pancancer drug sensitivity. We gathered cancer drug sensitivity data from publicly available databases (GEO, TCGA and GDSC) and developed a web tool called Comprehensive Pancancer Analysis of Drug Sensitivity (CPADS) using Shiny. CPADS currently includes transcriptomic data from over 29 000 samples, encompassing 44 types of cancer, 288 drugs and more than 9000 gene perturbations. It allows easy execution of various analyses related to cancer drug sensitivity. With its large sample size and diverse drug range, CPADS offers a range of analysis methods, such as differential gene expression, gene correlation, pathway analysis, drug analysis and gene perturbation analysis. Additionally, it provides several visualization approaches. CPADS significantly aids physicians and researchers in exploring primary and secondary drug resistance at both gene and pathway levels. The integration of drug resistance and gene perturbation data also presents novel perspectives for identifying pivotal genes influencing drug resistance. Access CPADS at https://smuonco.shinyapps.io/CPADS/ or https://robinl-lab.com/CPADS.© The Author(s) 2024. Published by Oxford University Press.

基金：
NaturalScienceFoundationofGuangdongProvince(2018A030313846and2021A1515012593),theScienceandTechnologyPlanningProjectofGuangdongProvince(2019A030317020),theNationalNaturalScienceFoundationofChina(81802257,81871859,81772457,82172750and82172811),GuangDongBasicandAppliedBasicResearchFoundation(Guangdong-GuangzhouJointFouds)(2022A1515111212),MedicalScienceandTechnologyProjectofSichuanProvincialHealthCommission(Number21PJ153).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 生物学
小类 | 1 区 生化研究方法 1 区 数学与计算生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOCHEMICAL RESEARCH METHODS Q1 MATHEMATICAL & COMPUTATIONAL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Avenue Zhong, Guangzhou, Guangdong, China. [2]The Second School of Clinical Medicine, Southern Medical University, No. 253, Industrial Avenue Zhong, Guangzhou, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Avenue Zhong, Guangzhou, Guangdong, China. [3]Thoracic Surgery Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, Maryland 20850, United States. [8]Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, China. [9]Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, China.
推荐引用方式(GB/T 7714)：
Li Kexin,Yang Hong,Lin Anqi,et al.CPADS: a web tool for comprehensive pancancer analysis of drug sensitivity[J].Briefings In Bioinformatics.2024,25(3):doi:10.1093/bib/bbae237.
APA：
Li Kexin,Yang Hong,Lin Anqi,Xie Jiayi,Wang Haitao...&Wei Ting.(2024).CPADS: a web tool for comprehensive pancancer analysis of drug sensitivity.Briefings In Bioinformatics,25,(3)
MLA：
Li Kexin,et al."CPADS: a web tool for comprehensive pancancer analysis of drug sensitivity".Briefings In Bioinformatics 25..3(2024)

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