机构：[1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]National Engineering Biomaterials, Sichuan University Research Center for Chengdu, Chengdu 610064, China.[3]NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials, Institute of Regulatory Science for Medical Devices, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in adolescents. Conventional treatment methods comprise extensive surgical resection, radiotherapy, and chemotherapy. Consequently, the management of bone tumors and bone regeneration poses significant clinical challenges. Photothermal tumor therapy has attracted considerable attention owing to its minimal invasiveness and high selectivity. However, key challenges have limited its widespread clinical use. Enhancing the tumor specificity of photosensitizers through targeting or localized activation holds potential for better outcomes with fewer adverse effects. Combinations with chemotherapies or immunotherapies also present avenues for improvement. In this review, we provide an overview of the most recent strategies aimed at overcoming the limitations of photothermal therapy (PTT), along with current research directions in the context of bone tumors, including (1) target strategies, (2) photothermal therapy combined with multiple therapies (immunotherapies, chemotherapies, and chemodynamic therapies, magnetic, and photodynamic therapies), and (3) bifunctional scaffolds for photothermal therapy and bone regeneration. We delve into the pros and cons of these combination methods and explore current research focal points. Lastly, we address the challenges and prospects of photothermal combination therapy.
基金：
This work was funded by the Science and Technology Research Program of SichuanProvince. Grant/Award Number: 2023NSFSC0733.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|2 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China.
通讯作者：
通讯机构：[2]National Engineering Biomaterials, Sichuan University Research Center for Chengdu, Chengdu 610064, China.[3]NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials, Institute of Regulatory Science for Medical Devices, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
推荐引用方式(GB/T 7714)：
Xie Mengzhang,Gong Taojun,Wang Yitian,et al.Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors[J].International Journal Of Molecular Sciences.2024,25(8):doi:10.3390/ijms25084139.
APA：
Xie Mengzhang,Gong Taojun,Wang Yitian,Li Zhuangzhuang,Lu Minxun...&Zhou Yong.(2024).Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors.International Journal Of Molecular Sciences,25,(8)
MLA：
Xie Mengzhang,et al."Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors".International Journal Of Molecular Sciences 25..8(2024)
