详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Synthesis of BSA-Coated BiOI@Bi2 S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor.

文献详情

资源类型：

收录情况： ◇ EI ◇ 自然指数

作者：

机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. [2]College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China. [3]College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu, Sichuan, 610041, China. [4]CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100190, China. [5]Department of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China. [6]School of Material Science and Engineering, Institute of Nano Engineering, Shandong University of Science and Technology, Qingdao, Shandong, 266590, China.

出处：

DOI：

ISSN：

摘要：

Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi2 S3 @BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi2 S3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2017]版：

大类 | 1 区

工程技术

小类 | 1 区化学综合 1 区物理化学 1 区材料科学：综合 1 区纳米科技 1 区物理：应用 1 区物理：凝聚态物理

最新[2023]版：

大类 | 1 区

材料科学

小类 | 1 区化学：综合 1 区物理化学 1 区材料科学：综合 1 区纳米科技 1 区物理：应用 1 区物理：凝聚态物理

第一作者：

第一作者机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. [2]College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.

通讯作者：

通讯机构： [1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. [2]College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China. [4]CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, 100190, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：