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Targeting PRAME for acute myeloid leukemia therapy

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机构： [1]Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Dermatology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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关键词： PRAME acute myeloid leukemia leukemia-associated antigen minimal residual disease immunotherapy adoptive T-cell therapy

摘要：

Despite significant progress in targeted therapy for acute myeloid leukemia (AML), clinical outcomes are disappointing for elderly patients, patients with less fit disease characteristics, and patients with adverse disease risk characteristics. Over the past 10 years, adaptive T-cell immunotherapy has been recognized as a strategy for treating various malignant tumors. However, it has faced significant challenges in AML, primarily because myeloid blasts do not contain unique surface antigens. The preferentially expressed antigen in melanoma (PRAME), a cancer-testis antigen, is abnormally expressed in AML and does not exist in normal hematopoietic cells. Accumulating evidence has demonstrated that PRAME is a useful target for treating AML. This paper reviews the structure and function of PRAME, its effects on normal cells and AML blasts, its implications in prognosis and follow-up, and its use in antigen-specific immunotherapy for AML.Copyright © 2024 Yang, Chen, Ye and Ma.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.

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