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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations

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收录情况： ◇ SCIE

作者：
Li Fei[1] * ; Xiang Run[1,2] * ; Liu Yue[1] ; Hu Guoliang[1] ; Jiang Quanbo[3] ; Jia Tao[1,4,5,*1] ;
机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China [2]Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China [3]Light, Nanomaterials, Nanotechnologies (L2n) Laboratory, CNRS EMR 7004, University of Technology of Troyes, 12 rue Marie Curie, 10004 Troyes, France [4]CNRS-UMR9187, INSERM U1196, PSL-Research University, 91405 Orsay, France e CNRS-UMR9187, INSERM U1196, Universit´ [5]Paris Saclay, 91405 Orsay, France
出处：
DOI： 10.1016/j.cellsig.2024.111123
ISSN：

关键词： Mitochondrial genome variations Heteroplasmy Single molecular tools

摘要：
Mitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose of manipulation of mitochondria or mitochondrial genome for therapeutics. Understanding the scope and limitations of above strategies is not only fundamental to the understanding of basic biology but also critical for exploring disease-related novel target(s), as well to develop innovative therapies. Here, this review provides an overview of different tools and techniques for accurate mitochondrial genome variations identification, quantification, and discuss novel strategies for the manipulation of mitochondria to develop innovative therapeutic interventions, through combining the insights gained from the study of mitochondrial genetics with ongoing single cell omics combined with advanced single molecular tools.Copyright © 2023. Published by Elsevier Inc.

基金：
This research was funded by Science and Technology Department of Sichuan Province 2023NSFSC0130 and 2023NSFSC1992 to TJ, Startup Foundation for Advanced Talents of Sichuan University (YJ2021124) to TJ, as well as the supports from “the Fundamental Research Funds for the Central Universities” and Institute Curie to TJ. RX was sponsored by Natural Science Foundation of Sichuan (2023NSFSC1463).
语种：
外文
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中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China [4]CNRS-UMR9187, INSERM U1196, PSL-Research University, 91405 Orsay, France e CNRS-UMR9187, INSERM U1196, Universit´ [5]Paris Saclay, 91405 Orsay, France [*1]West China School of Pharmacy, Sichuan University, No.17, Block 3, Southern Renmin Road, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Li Fei,Xiang Run,Liu Yue,et al.Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations[J].CELLULAR SIGNALLING.2024,117:111123.doi:10.1016/j.cellsig.2024.111123.
APA：
Li Fei,Xiang Run,Liu Yue,Hu Guoliang,Jiang Quanbo&Jia Tao.(2024).Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations.CELLULAR SIGNALLING,117,
MLA：
Li Fei,et al."Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations".CELLULAR SIGNALLING 117.(2024):111123

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