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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations

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机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China [2]Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China [3]Light, Nanomaterials, Nanotechnologies (L2n) Laboratory, CNRS EMR 7004, University of Technology of Troyes, 12 rue Marie Curie, 10004 Troyes, France [4]CNRS-UMR9187, INSERM U1196, PSL-Research University, 91405 Orsay, France e CNRS-UMR9187, INSERM U1196, Universit´ [5]Paris Saclay, 91405 Orsay, France

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关键词： Mitochondrial genome variations Heteroplasmy Single molecular tools

摘要：

Mitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose of manipulation of mitochondria or mitochondrial genome for therapeutics. Understanding the scope and limitations of above strategies is not only fundamental to the understanding of basic biology but also critical for exploring disease-related novel target(s), as well to develop innovative therapies. Here, this review provides an overview of different tools and techniques for accurate mitochondrial genome variations identification, quantification, and discuss novel strategies for the manipulation of mitochondria to develop innovative therapeutic interventions, through combining the insights gained from the study of mitochondrial genetics with ongoing single cell omics combined with advanced single molecular tools.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2023]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

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出版当年[2023]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY

影响因子： 4.4 最新[2023版] 4.4 最新五年平均 4.4 出版当年[2023版] 0 出版当年五年平均 4.4 出版前一年[2023版]

第一作者：

第一作者机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

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通讯作者：

通讯机构： [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China [4]CNRS-UMR9187, INSERM U1196, PSL-Research University, 91405 Orsay, France e CNRS-UMR9187, INSERM U1196, Universit´ [5]Paris Saclay, 91405 Orsay, France [*1]West China School of Pharmacy, Sichuan University, No.17, Block 3, Southern Renmin Road, Chengdu 610041, China.

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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations

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