详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [2]Colorectal Cancer Center, Department of General Surgery, West China Tianfu Hospital, Sichuan University, 610041 Chengdu, Sichuan, China. [3]Department of Critical Care Medicine, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [4]The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [5]The Center of Obesity and Metabolism disease, Department of General surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [6]Medical Research Center, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China.

出处：

DOI：

ISSN：

关键词： colon adenocarcinoma; metabolic reprogramming; purine metabolism; immune-metabolic checkpoints

摘要：

Metabolic reprogramming provides a new perspective for understanding cancer. The targeting of dysregulated metabolic pathways may help to reprogram the immune status of the tumor microenvironment (TME), thereby increasing the effectiveness of immune checkpoint therapy. Colorectal cancer (CRC), especially colon adenocarcinoma (COAD), is associated with poor patient survival. The aim of the present study was to identify novel pathways involved in the development and prognosis of COAD, and to explore whether these pathways could be used as targets to improve the efficacy of immunotherapy.Metabolism-related differentially expressed genes (MRDEGs) between tumor and normal tissues were identified using The Cancer Genome Atlas (TCGA) dataset, together with metabolism-related prognostic genes (MRPGs). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed separately for the MRDEGs and MRPGs. Gene Set Variation Analysis (GSVA) was also performed to explore the role of purine metabolism in COAD tumorigenesis. Consensus clustering of purine metabolism genes with the overall survival (OS) of patients and with anti-tumor immunity was also performed. Pearson correlation analysis was used to identify potential targets that correlated strongly with the expression of immune checkpoints.A 6-gene signature that had independent prognostic significance for COAD was identified, together with a predictive model for risk stratification and prognosis. The most significantly enriched pathway amongst MRDEGs and MRPGs was purine metabolism. Differentially expressed purine metabolism genes could divide patients into two clusters with distinct prognosis and anti-tumor immunity. Further analysis suggested that purine metabolism was involved in anti-tumor immunity.This study confirmed the importance of metabolism-related pathways and in particular purine metabolism in the tumorigenesis, prognosis and anti-tumor immunity of COAD. We identified a 6-gene prognostic signature comprised of EPHX2, GPX3, PTGDS, NAT2, ACOX1 and CPT2. In addition, four potential immune-metabolic checkpoints (GUCY1A1, GUCY1B1, PDE1A and PDE5A) were identified, which could be used to improve the efficacy of immunotherapy in COAD.© 2023 The Author(s). Published by IMR Press.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, 610031 Chengdu, Sichuan, China.

共同第一作者：

通讯作者：

通讯机构： [4]The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [5]The Center of Obesity and Metabolism disease, Department of General surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China. [6]Medical Research Center, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, 610031 Chengdu, Sichuan, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma

文献详情

相关文献