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Immune-stealth carboxymethyl chitosan-based nanomaterials for magnetic resonance imaging-guided photothermal therapy.

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机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China [2]Med-X Center for Materials, Sichuan University, Chengdu 610041, China [3]Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China [4]Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China [5]Department of Orthopedics, The Second Affiliated Hospital of Dalian Medical University, Dalian, China

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Numerous protein-based multifunctional nanomaterials have been studied for biomedical applications. However, the inherent immunogenicity and activation of the complement system of protein-based nanomaterials may cause immunological responses, further leading to hypersensitivity and/or allergic reactions in patients. Herein, carboxymethyl chitosan (CMC) and KMnO4 are used to develop polysaccharide-based MnO2 (CM) nanoparticles as facile, effective and low-immunogenicity nanomaterials for magnetic resonance imaging (MRI)-guided photothermal therapy (PTT). As a proof of concept, indocyanine green (ICG) is loaded in the CM nanoplatform to form a CMC-MnO2-ICG compound (CMI) for MRI-guided photothermal therapy. In vitro studies show that the proposed CMC-based nanomaterials exhibit excellent hemocompatibility and no significant complement activation. The in vivo biosafety experiments also show that the CMC-based nanomaterials have low immunogenicity and will not cause tissue damage. Moreover, the prepared CMI nanoparticles (NPs) possess outstanding photothermal properties and high longitudinal relaxivity (8.47 mM-1 s-1), which achieve successful MRI-guided PTT in tumor-bearing mice. This work draws increasing attention to the hemocompatibility and immunogenicity of high-performance nanoprobes for biomedical applications.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2022]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 1 区有机化学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

第一作者：

第一作者机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China [2]Med-X Center for Materials, Sichuan University, Chengdu 610041, China

通讯作者：

通讯机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China [2]Med-X Center for Materials, Sichuan University, Chengdu 610041, China [*1]Med-X Center for Materials, Sichuan University, Chengdu 610041, China.

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