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The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China

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机构: [1]Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
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关键词: acute myeloid leukemia event-free survival overall survival PTPN11

摘要:
The clinical significance of protein tyrosine phosphatase nonreceptor type 11 mutation (PTPN11mut ) in acute myeloid leukemia (AML) is underestimated.We collected the data of AML patients with mutated PTPN11 and wild-type PTPN11 (PTPN11wt ) treated at our hospital and analyzed their clinical characteristics and prognosis.Fifty-nine PTPN11mut and 124 PTPN11wt AML patients were included. PTPN11mut was more common in myelomonocytic and monocytic leukemia, and was more likely to co-mutate with KRAS, KMT2C, NRAS, U2AF1, NOTCH1, IKZF1, and USH2A mutations than PTPN11wt . The overall survival for AML patients with PTPN11mut was significantly shorter than that for those with PTPN11wt (p = 0.03). The negative impact of PTPN11mut on overall survival was pronounced in the "favorable" and "intermediate" groups of ELN2017 risk stratification, as well as in the wild-type NPM1 group (p = 0.01, p = 0.01, and p = 0.04).PTPN11mut is associated with distinct clinical and molecular characteristics, and adverse prognosis in AML patients.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
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第一作者机构: [1]Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
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