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Logic gate controlled theranostic nanoagents for in situ microwave thermal therapeutic efficacy evaluation

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资源类型：
Pubmed体系：
作者：
Chen Zengzhen[1,2] * ; Guo Wenna[1,2,5] ; Liang Tiansong[4] ; Zheng Yingjuan[4] ; Niu Meng[6] ; Yang Daoke[4] ; Tan Longfei[1,2] ; Fu Changhui[1,2] ; Wu Qiong[1,2] ; Ren Xiangling[1,2] ; Yu Jie[3] ; Liang Ping[3] ; Ren Jun[1,2] ; Meng Xianwei[1,2,*1] ;
机构： [1]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China [2]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China [3]Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, 100853, China [4]Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China [5]School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan, China [6]Department of Radiology, First Hospital of China Medical University Key Laboratory of Diagnostic Imaging and Interventional Radiology in Liaoning Province,
出处：
DOI： 10.1016/j.biomaterials.2023.122299
ISSN：

关键词： A logic AND gate Activatable Microwave thermal therapy Real-time imaging Theranostics

摘要：
In vivo monitoring of treatment response is of great significance for tumor therapy in clinical trials, but it remains a formidable challenge. Herein, we demonstrate a logic AND gate theranostic nanoagent that responds to the coexistence of endogenous and exogenous stimuli, namely HAuCl4@1-Tetradecanol@Gd-based metal-organic framework@SiO2 nanocomposites (APGS NCs). Upon microwave (MW) irradiation, HAuCl4 in the inner part of APGS NCs reacts with the tumor-associated glutathione (GSH). Subsequently, it transforms into an active luminescent form of Au@1-Tetradecanol@Gd-MOF@SiO2 nanocomposites (AuPGS NCs). The intensity of generated fluorescence is correlated with the tumor thermal-injury status. Thus, the generation of AuPGS NCs with high intensity fluorescence under the co-activation of MW and GSH can visualize the treatment effects during MW thermal therapy and instantly modulate the irradiation time and range for optimal outcomes. Hence, this logic gate controlled APGS NCs makes MW thermal therapy eliminate tumor cells completely. This research offers an effective strategy for the design and preparation of activatable theranostic nanoagents for precise tumor imaging and therapy.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China [grant numbers: U20A20335, 91859201], and Beijing Natural Science Foundation [grant numbers: 4222019].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
第一作者：
第一作者机构： [1]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China [2]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
通讯作者：
通讯机构： [1]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China [2]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China [*1]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
推荐引用方式(GB/T 7714)：
Chen Zengzhen,Guo Wenna,Liang Tiansong,et al.Logic gate controlled theranostic nanoagents for in situ microwave thermal therapeutic efficacy evaluation[J].Biomaterials.2023,302:122299.doi:10.1016/j.biomaterials.2023.122299.
APA：
Chen Zengzhen,Guo Wenna,Liang Tiansong,Zheng Yingjuan,Niu Meng...&Meng Xianwei.(2023).Logic gate controlled theranostic nanoagents for in situ microwave thermal therapeutic efficacy evaluation.Biomaterials,302,
MLA：
Chen Zengzhen,et al."Logic gate controlled theranostic nanoagents for in situ microwave thermal therapeutic efficacy evaluation".Biomaterials 302.(2023):122299

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