机构：[1]College of Materials Science & Engineering, Sichuan University, Chengdu 610065, China [2]Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry Chinese Academy of Sciences, Beijing 100190, China [3]Department of Orthopaedics, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
The zeolitic imidazolate framework-8 (ZIF-8) is a specifically promising drug carrier due to its excellent intrinsic properties. However, the high toxicity of ZIF-8 nanoparticles severely limits their further research and clinical application. In this work, the biocompatibility of ZIF-8 nanoparticles is greatly improved by coating ZrO2 onto the surface. The survival rate of cells and mice in the ZIF-8@ZrO2 nanocomposite group is significantly increased compared with the undecorated ZIF-8 nanoparticle group. Doxorubicin (DOX) as a chemotherapeutic drug is deposited during the ZIF-8 growth by a facile one-pot method. Ionic liquid (IL) is loaded into the pore of the ZIF-8/DOX@ZrO2 nanocomposites for enhancing microwave thermal therapy. The tumor inhibition rate of ZIF-8/DOX@ZrO2@IL nanocomposites with synergistic microwave thermal therapy and chemotherapy is obviously higher than in other groups. In addition, the ZIF-8/DOX@ZrO2@IL nanocomposites are used for real-time monitoring of the therapeutic outcomes due to the excellent computed tomography contrast agent, ZrO2. Therefore, such a ZrO2 coating strategy shows great promise for overcoming high toxicity of ZIF-8 nanoparticles, which offers a new platform for tumor synergistic microwave thermal therapy and chemotherapy using the ZIF-8/DOX@ZrO2@IL nanocomposite as a theranostic nanocarrier.
基金：
the National Natural Science Foundation of China (91859201, 81630053).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|1 区材料科学
小类|2 区纳米科技2 区材料科学：综合
最新[2023]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]College of Materials Science & Engineering, Sichuan University, Chengdu 610065, China [2]Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry Chinese Academy of Sciences, Beijing 100190, China
通讯作者：
推荐引用方式(GB/T 7714)：
Su Liuhui,Wu Qiong,Tan Longfei,et al.High Biocompatible ZIF-8 Coated by ZrO2 for Chemo-microwave Thermal Tumor Synergistic Therapy.[J].ACS applied materials & interfaces.2019,11(11):10520-10531.doi:10.1021/acsami.8b22177.
APA：
Su Liuhui,Wu Qiong,Tan Longfei,Huang Zhongbing,Fu Changhui...&Meng Xianwei.(2019).High Biocompatible ZIF-8 Coated by ZrO2 for Chemo-microwave Thermal Tumor Synergistic Therapy..ACS applied materials & interfaces,11,(11)
MLA：
Su Liuhui,et al."High Biocompatible ZIF-8 Coated by ZrO2 for Chemo-microwave Thermal Tumor Synergistic Therapy.".ACS applied materials & interfaces 11..11(2019):10520-10531
材料科学