A core-shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy.
机构：[1]College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.[2]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.[3]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Beijing 100190, China.[4]Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China.[5]Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
The presence of high content glutathione (GSH) provides an effective "protective shield" for tumor cells, which undoubtedly is a huge impediment to reactive oxygen species (ROS)-based treatment. Fortunately, divalent copper (Cu2+) can not only consume GSH, destroying the protection mechanism of GSH, but also can be reduced to Cu+ with excellent Fenton-like reaction activity. Hence, capitalizing on the properties of liquid metals, we introduced Cu with three different valances via an in situ replacement reaction. A stable core-shell liquid-metal based "Cu storage pool" was obtained. It can effectively deplete GSH within the cells, and simultaneously produce ·OH through a Fenton-like reaction, further improving the effect of chemodynamic therapy (CDT). Under microwave irradiation, it is also capable of producing a large amount of ROS to promote tumor treatment. In addition, the loading of ionic liquid endows LZC@IL nanoparticles with certain microwave heating performance, which is able to augment microwave thermal therapy (MWTT). With the combination of CDT, microwave dynamic therapy (MDT) and MWTT, LZC@IL has an excellent effect on tumor elimination. This work offers a new idea for the application of liquid metals and the combined treatment of tumors, which has potential application value.
基金：
National Natural Science Foundation of China (Project No. U20A20335,
62001456, and 91859201), the Beijing Natural Science
Foundation (Project No. 4222019 and 7212208), and the
Sichuan Science and Technology Program (Project No.
2020YFSY0018).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区工程技术
小类|2 区材料科学：生物材料
最新[2023]版：
大类|3 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.[2]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.[3]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Beijing 100190, China.
通讯作者：
通讯机构：[2]Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.[3]CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Beijing 100190, China.
推荐引用方式(GB/T 7714)：
Yu Yongnian,Wu Qiong,Niu Meng,et al.A core-shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy.[J].Biomaterials science.2022,doi:10.1039/d2bm00435f.
APA：
Yu Yongnian,Wu Qiong,Niu Meng,Gou Li,Tan Longfei...&Meng Xianwei.(2022).A core-shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy..Biomaterials science,,
MLA：
Yu Yongnian,et al."A core-shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy.".Biomaterials science .(2022)
