详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Heat Shock Proteins in Non-Small-Cell Lung Cancer-Functional Mechanism

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China. [2]Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, 610041 Chengdu, Sichuan, China. [3]Department of Burn and Reconstructive Surgery, Laboratory of Mitochondria and Metabolism, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China. [4]Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 999077 Hong Kong, China.

出处：

DOI：

ISSN：

关键词： Heat shock proteins; non-small cell lung cancer; apoptotic

摘要：

Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers, which has the highest cancer-related mortality worldwide. Regardless of the therapeutic effects of chemotherapy or targeted therapy, drug resistance will occur after 1 year. Heat shock proteins (HSPs) are a class of molecular chaperones participated in protein stability and multiple intracellular signaling pathways. It has been widely reported that HSPs family is over expressed in non-small cell lung cancer, and these molecules are also associated with protein stability and multiple intracellular signaling pathways. The effect of chemotherapy drugs or targeted drugs on cancer cells is usually to induce apoptosis. It is necessary to explore the interaction between heat shock protein family and apoptosis pathway in NSCLC. Here we provide a brief review of how HSPs affect the apoptotic pathway in NSCLC.© 2023 The Author(s). Published by IMR Press.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China. [2]Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, 610041 Chengdu, Sichuan, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China. [2]Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, 610041 Chengdu, Sichuan, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Heat Shock Proteins in Non-Small-Cell Lung Cancer-Functional Mechanism

文献详情

相关文献