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Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases

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资源类型：
Pubmed体系：
作者：
Xin Xin[1] ; Wang Yue[2] ; Zhang Lele[1] ; Zhang Dan[1] ; Sha Leihao[1] ; Zhu Ziyu[1] ; Huang Xiaoyi[1] ; Mao Wuyu[1] ; Zhang Jifa[1] ;
机构： [1]Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China [2]Leling Traditional Chinese Medicine Hospital, Leling, 253600, Shandong, China
出处：
DOI： 10.1016/j.ejmech.2023.115102
ISSN：

关键词： AAK1 Small molecule inhibitors Structure-activity relationships (SARs) Anti-neuropathic pain Broad-spectrum antiviral target

摘要：
Adaptor-Associated Kinase 1 (AAK1), a Ser/Thr protein kinase, responsible for regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS). AAK1 plays an important role in neuropathic pain and a variety of other human diseases, including viral invasion, Alzheimer's disease, Parkinson's syndrome, etc. Therefore, targeting AAK1 is a promising therapeutic strategy. However, although small molecule AAK1 inhibitors have been vigorously developed, only BMS-986176/LX-9211 has entered clinical trials. Simultaneously, new small molecule inhibitors, including BMS-911172 and LP-935509, exhibited excellent druggability. This review elaborates on the structure, biological function, and disease relevance of AAK1. We emphatically analyze the structure-activity relationships (SARs) of small molecule AAK1 inhibitors based on different binding modalities and discuss prospective strategies to provide insights into novel AAK1 therapeutic agents for clinical practice.Copyright © 2023. Published by Elsevier Masson SAS.

基金：
National Natural Science Foundation of China (81903502, 22277083), and Natural Science Foundation of Sichuan Province (2022NSFSC1365, 2022NSFSC1187).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 1 区 药物化学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 药物化学
第一作者：
第一作者机构： [1]Joint Research Institution of Altitude Health, State Key Laboratory of Biotherapy and Cancer Center, Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xin Xin,Wang Yue,Zhang Lele,et al.Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases[J].European journal of medicinal chemistry.2023,248:115102.doi:10.1016/j.ejmech.2023.115102.
APA：
Xin Xin,Wang Yue,Zhang Lele,Zhang Dan,Sha Leihao...&Zhang Jifa.(2023).Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases.European journal of medicinal chemistry,248,
MLA：
Xin Xin,et al."Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases".European journal of medicinal chemistry 248.(2023):115102

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