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Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: A systematic review and meta-analysis of 13,110 patients

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资源类型：
Pubmed体系：
作者：
Xu Hang[1,2] ; Zheng Xiaonan[1,2] ; Ai Jianzhong[1,2,*1] ; Yang Lu[1,2,*1] ;
机构： [1]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
出处：
DOI： 10.1016/j.intimp.2022.109496
ISSN：

关键词： Biomarker HALP score Cancer Prognosis Meta-analysis

摘要：
We sought to explore the prognostic role of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score on survival outcomes in patients with solid tumors by performing a systematic review and meta-analysis.PubMed, EMBASE and Web of Science were searched for relevant articles through 02 Nov 2022. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted and pooled to assess the association of the HALP score with survival outcomes in solid tumors using Stata 15.0. The primary outcome was overall survival (OS), and the secondary outcomes were cancer-specific survival (CSS) and progression/disease/recurrence-free survival (PFS/DFS/RFS).A total of 28 studies (31 cohorts) comprising 13,038 patients were enrolled. A low HALP score was associated with decreased OS (HR, 1.61; 95 % CI, 1.44-1.81; P < 0.001), CSS (HR, 1.80; 95 % CI: 1.54-2.09; P < 0.001) and PFS/DFS/RFS (HR, 1.61; 95 % CI: 1.45-1.80; P < 0.001). The prognostic value of HALP on OS was observed across various tumor types and tumor stages. meta-regression found that tumor stage was the major source of the heterogeneity for OS.A low pretreatment HALP score is a reliable and negative prognostic biomarker for survival outcomes in patients with cancer.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (82070784,81702536) to J.A., a grant from the Science & Technology Department of Sichuan Province, China (2022JDRC0040) to J.A., grants from The National Natural Science Foundation of China (Grant Nos. 81974099, 82170785) to L.Y., a grant from the Science and Technology Department of Sichuan Province (Grant Nos. 2021YFH0172) to L.Y., a grant from the Young Investigator Award of Sichuan University 2017 (Grant No. 2017SCU04A17) to L.Y., a grant from the Sichuan University-Panzhihua science and technology cooperation special fund (2020CDPZH-4) to L.Y., and grants from the China Postdoctoral Science Foundation (No. 2021 M692306) and PostDoctor Research Project of West China Hospital of Sichuan University (2021HXBH025) to X.Z.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
第一作者：
第一作者机构： [1]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2]Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China [*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
推荐引用方式(GB/T 7714)：
Xu Hang,Zheng Xiaonan,Ai Jianzhong,et al.Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: A systematic review and meta-analysis of 13,110 patients[J].International immunopharmacology.2022,114:109496.doi:10.1016/j.intimp.2022.109496.
APA：
Xu Hang,Zheng Xiaonan,Ai Jianzhong&Yang Lu.(2022).Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: A systematic review and meta-analysis of 13,110 patients.International immunopharmacology,114,
MLA：
Xu Hang,et al."Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: A systematic review and meta-analysis of 13,110 patients".International immunopharmacology 114.(2022):109496

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