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The role of circular RNAs in the pathophysiology of oral squamous cell carcinoma

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机构: [1]Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia [2]Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. [3]Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, Russia. [4]Gastric Cancer Center, West China Hospital of Sichuan University, China. [5]Department of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, Russia. [6]Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia. [7]Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
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关键词: Non-coding RNAs Circular RNAs Biology function Oral squamous cell carcinoma Biomarker

摘要:
Circular RNAs are non-coding RNAs that widely exist in eukaryotes. The research progress of its generation mechanism and biological function show that circular RNAs may be used in the development of tumors, neurological diseases, cardiovascular diseases. They play an important role in the occurrence and development of diseases and has a potential to be used as a disease marker. Oral squamous cell carcinoma is one of the most common malignant tumors in oral surgery. It is difficult to treat, easy to metastasize, and has a poor prognosis. Due to its unclear mechanism, blocking oral squamous cell carcinoma at the genetic level cannot be achieved. The research progress of circular RNA in the field of oral squamous cell carcinoma will bring new ideas for the biological treatment of oral squamous cell carcinoma. This review summarizes the circRNAs mechanism, the biological function and the research progress in the development of tumors, especially oral squamous cell carcinoma.© 2022 The Authors.

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出版当年[2023]版:
大类 | 3 区 生物学
小类 | 3 区 生化与分子生物学
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 生化与分子生物学
第一作者:
第一作者机构: [1]Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia [2]Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
通讯作者:
通讯机构: [1]Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia [*1]Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.
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