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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects

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机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China [2]Experimental and Research Animal Institute, Sichuan University, Chengdu 610065, China [3]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China [4]Med-X Center for Materials, Sichuan University, 610041, China

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关键词： Bone tumor Chitosan Photothermal treatment Black phosphorus Hydroxyapatite

摘要：

After bone tumor resection, the severe complications including cancer recurrence, infection and extensive bone loss are still a challenge. To address this problem, a chitosan/hydroxypropyltrimethyl ammonium chloride chitosan/hydroxyapatite/black phosphorus (CS/HC/HA/BP) hybrid photothermal scaffold with a multistage photothermal strategy was developed. HC-stabilized BP endowed the scaffold with simultaneous antitumor/antibacterial properties under photothermal stimulation of <50 °C. Subsequently, excellent osteogenesis could be achieved with mild hyperthermia stimulation (∼42 °C) through up-regulating the expressions of heat shock proteins. Under NIR irradiation, the scaffold could eliminate 95 % of osteosarcoma cells as well as 97 % of E. coli and 92 % of S. aureus. The osteogenic gene expressions of ALP, COL 1A1, and OCN in photothermal group were 1.64, 1.31 and 1.27 folds higher than that of non-photothermal group in vivo, respectively. Therefore, the obtained scaffold synergized with multistage photothermal strategy was effective and a reference for the treatment of other complex diseases.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

第一作者：

第一作者机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

通讯作者：

通讯机构： [1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China [3]State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China [4]Med-X Center for Materials, Sichuan University, 610041, China [*1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.

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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects

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