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Computational hemodynamic analysis for optimal stent position in the transjugular intrahepatic portosystemic shunt procedure

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机构: [1]Department of Applied Mechanics, Sichuan University, Chengdu 610065, China [2]Sichuan University Yibin Park / Yibin Institute of Industrial Technology, Yibin 644000, China [3]Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, Sichuan University, Chengdu, China [4]Med-X Center for Informatics, Sichuan University, Chengdu 610041, China [5]No. 24 South Section of First Ring Road, Chengdu 610065, Sichuan Province, China
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关键词: Portal pressure Transjugular intrahepatic portosystemic shunt (TIPS) Hemodynamics Shunting flowrate

摘要:
Transjugular intrahepatic portosystemic shunt (TIPS) is an effective treatment for portal hypertension (PH). The current study aimed to investigate the effect of stent position on post-TIPS hemodynamic performance using computational fluid dynamics. Patient-specific pre- and post-TIPS models were reconstructed from CT images of two patients, then virtual TIPS models were created by shifting the portal vein (PV) entry site of the stent. Although there were marginal differences the effects of left-sided and right-sided TIPS on post-TIPS portal pressure and shunting flow, right-sided TIPS resulted in a greater proportion of superior mesenteric vein (SMV) flow diverting to stents compared to that for left-sided TIPS. The results also demonstrated that the nearer the entry site of stent to the portal venous bifurcation, the greater and more stable the shunting blood flow. These results suggest that the entry site of the stent should be as close to the portal vein bifurcation as possible during TIPS. TIPS on the right branch of the portal vein may be more likely to result in post-TIPS hepatic encephalopathy than that on the left branch.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2022]版:
大类 | 3 区 工程技术
小类 | 2 区 生物物理 3 区 工程:生物医学
最新[2023]版:
大类 | 3 区 医学
小类 | 2 区 生物物理 3 区 工程:生物医学
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第一作者机构: [1]Department of Applied Mechanics, Sichuan University, Chengdu 610065, China [2]Sichuan University Yibin Park / Yibin Institute of Industrial Technology, Yibin 644000, China [5]No. 24 South Section of First Ring Road, Chengdu 610065, Sichuan Province, China
通讯作者:
通讯机构: [1]Department of Applied Mechanics, Sichuan University, Chengdu 610065, China [4]Med-X Center for Informatics, Sichuan University, Chengdu 610041, China [5]No. 24 South Section of First Ring Road, Chengdu 610065, Sichuan Province, China
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