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Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations

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Pubmed体系：
作者：
Xue Mei Fang[1,2] ; Ying Liu[1,2,3] ; Ji Wang[1,2] ; Xin Zhang[1,2,3] ; Lei Wang[2,3] ; Li Zhang[1,2,3] ; Hong Ping Zhang[1,2,3] ; Lei Liu[1,2,3] ; Dan Huang[1,2,3] ; Dan Liu[1,2] ; Ke Deng[1,2] ; Feng Ming Luo[1,2] ; Hua Jing Wan[1,2] ; Wei Min Li[1,4] ; Gang Wang[1,2] ; Brian G. Oliver[5,6] ;
机构： [1]Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [2]Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease‑Related Molecular Network, Sichuan University, Chengdu 610041, Sichuan, China [3]Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [4]Respiratory Microbiome Laboratory, Frontiers Science Center for Disease‑Related Molecular Network, Sichuan University, Chengdu, Sichuan, China [5]School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia [6]Respiratory Cellular and Molecule Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2017, Australia
出处：
DOI： 10.1007/s00408-022-00570-x
ISSN：

关键词： Adenosine 5′-monophosphate Acetylcholine Histamine Asthma control Asthma exacerbation

摘要：
Endogenous adenosine 5'-monophosphate (AMP), acetylcholine (ACh), and histamine (HA) are known to be important in bronchial contraction, but their clinical relevance to asthma is poorly understood. We aimed to quantify endogenous AMP, ACh, and HA in induced sputum samples and explore their relationships with asthma control and exacerbations.20 healthy subjects and 112 asthmatics underwent clinical assessment, sputum induction, and blood sampling. The level of asthma control was determined by the asthma control test (ACT) questionnaire. Asthma exacerbation was evaluated according to the criteria of the American Thoracic Society/European Respiratory Society. Levels of AMP, ACh, and HA in sputum were measured by liquid chromatography coupled to tandem mass spectrometry. IL-β, IL-4, IL-5, IL-6, IL-8, IL-13, IL-17A, TNF-α, IFN-γ, and macrophage-derived chemokine (MDC) were also measured.Compared to healthy controls, asthmatics had higher levels of HA, lower levels of ACh, and similar levels of AMP in induced sputum samples. Compared to controlled asthma (n = 54), uncontrolled asthma (n = 58) showed higher AMP levels (P = 0.002), but similar HA and ACh levels. AMP was negatively correlated with ACT scores (r = - 0.348) and asthma quality of life questionnaire scores (r = - 0.188) and positively correlated with blood monocytes percentage (r = 0.195), sputum MDC (r = 0.214), and IL-6 levels (r = 0.196). Furthermore, AMP was associated with an increased risk of exacerbations in the preceding year.Endogenous AMP, but not ACh or HA, was associated with asthma control, quality of life, and exacerbations in the previous year, which indicates that AMP could be a clinically useful biomarker of asthma.© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

基金：
National Natural Science Foundation of China (Grant Nos. 81920108002, 81870027, and 81900026), and 1.3.5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (Grant No. 2018HXFH016), and Post-Doctor Research Project, West China Hospital, Sichuan University, China (Grant No. 2021HXBH013).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 呼吸系统
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 呼吸系统
第一作者：
第一作者机构： [1]Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [2]Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease‑Related Molecular Network, Sichuan University, Chengdu 610041, Sichuan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [2]Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease‑Related Molecular Network, Sichuan University, Chengdu 610041, Sichuan, China [4]Respiratory Microbiome Laboratory, Frontiers Science Center for Disease‑Related Molecular Network, Sichuan University, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Xue Mei Fang,Ying Liu,Ji Wang,et al.Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations[J].Lung.2022,200(5):579-589.doi:10.1007/s00408-022-00570-x.
APA：
Xue Mei Fang,Ying Liu,Ji Wang,Xin Zhang,Lei Wang...&Brian G. Oliver.(2022).Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations.Lung,200,(5)
MLA：
Xue Mei Fang,et al."Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations".Lung 200..5(2022):579-589

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