个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Chen Xun[1,3,6] ; Zhang Yujin[1,3,6] ; Pei Junxia[1,3,6] ; Zeng Xin[1,3,7] ; Yang Yixi[1,3,6] ; Zhang YaMei[5] ; Li Fulun[2,*1] ; Deng Yu[1,3,4,*1] ;
机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106, China [2]Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, NO. 110, Ganhe Road, Shanghai 200437, China [3]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106, China [4]School of Basic Medical Sciences, Chengdu University, NO. 2025, Chengluo Road, Chengdu 610106, China [5]Key Laboratory of Clinical Genetics, Affiliated Hospital of Chengdu University, Chengdu 610106, China [6]School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China [7]School of Pharmacy, Chengdu University, Chengdu 610106, China
出处：
DOI： 10.1016/j.intimp.2022.109270
ISSN：

关键词： Atopic dermatitis Phellopterin STAT3 activation TSLP IL-33

摘要：
Anti-inflammation medication is one of the most important treatment for people with atopic dermatitis (AD) which presents persistent type 2 inflammation in skin lesions. Interaction between activated keratinocytes and immune cells in AD skin lesions amplifies inflammatory signaling by augmenting production of cytokines, such as keratinocyte-derived thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33). Phellopterin is a bioactive compound isolated from ethanol extract of Angelica dahurica root which has been traditionally used for AD therapy in China. In the present study, we showed that Phellopterin possessed anti-type 2 inflammation activity and alleviated AD-like phenotypes including reduction in serum immunoglobulin E (IgE) levels and infiltration of eosinophils and mast cells in the AD-like skin lesions. Further molecular analysis found that Phellopterin suppressed phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Tyr705, and the expression of TSLP and IL-33 in epidermal keratinocytes of AD-like lesions. In vitro studies in cultured human keratinocytes demonstrated that STAT3 was required for interleukin-4 (IL-4)-induced overexpression of TSLP and IL-33. Phellopterin inhibited IL-4-induced activation of STAT3, which leaded to suppress the STAT3-mediated transcription of TSLP and IL-33. Our study suggested that Phellopterin is an active compound with bioactivities of anti- type 2 inflammation and STAT3 inactivation, thus allowing to be a promising candidate for AD topical therapy.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (Grant No. 82174202, No. 82074428), Natural Science Foundation of Sichuan Province (Grant No. 2022NSFSC0726), Municipal Commission of Science and Technology (Grant No. 20XD1423600), Clinical Research Plan of SHDC (Grant No. SHDC2020CR4041), Innovation Foundation of The Affiliated Hospital of Chengdu University (Grant No. CDFYCX202209) and Major Research and Development Plan of Tibet Autonomous Region (Grant No. XZ202201ZY0031G)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
第一作者：
第一作者机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106, China [3]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106, China [6]School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
共同第一作者：
通讯作者：
通讯机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106, China [2]Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, NO. 110, Ganhe Road, Shanghai 200437, China [3]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106, China [4]School of Basic Medical Sciences, Chengdu University, NO. 2025, Chengluo Road, Chengdu 610106, China [*1]School of Basic Medical Sciences, Chengdu University, NO. 2025, Chengluo Road, Chengdu 610106, China
推荐引用方式(GB/T 7714)：
Chen Xun,Zhang Yujin,Pei Junxia,et al.Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes[J].International immunopharmacology.2022,112:109270.doi:10.1016/j.intimp.2022.109270.
APA：
Chen Xun,Zhang Yujin,Pei Junxia,Zeng Xin,Yang Yixi...&Deng Yu.(2022).Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes.International immunopharmacology,112,
MLA：
Chen Xun,et al."Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes".International immunopharmacology 112.(2022):109270

相关文献

[1]医院后勤精细化管理策略研究 [2]个性化目标教学在神经外科护理实习生带教中的应用 [3]纳米增强免疫比浊法和高效液相色谱法检测化疗患者5-氟尿嘧啶血药浓度的比较 [4]徒手淋巴引流对乳腺癌术后淋巴水肿的治疗效果分析 [5]护理干预在减轻妇科恶性肿瘤腹部术后疼痛中的效果 [6]心理护理对肿瘤介入治疗患者生活质量的影响 [7]某院2400张门诊中成药处方分析 [8]人文关怀在恶性肿瘤护理中的应用效果分析 [9]综合护理干预对肺癌化疗患者生活质量的影响 [10]外涂万花油对化疗性静脉炎的预防及疗效

资源点击量：43377 今日访问量：0 总访问量：3120 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号