详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan. [2]The Center of Anesthesiology and Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan. [3]Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan. [4]Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. [5]Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

出处：

DOI：

ISSN：

关键词： chemokine CXCL13 CXCR5 tumor microenvironment

摘要：

Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue. Through interactions between chemokines and their receptors, various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells. In recent decades, a large volume of studies have revealed chemokines' role in the tumor microenvironment in regulating tumor growth, invasion, and/or metastasis as well as tumor immune response; however, their molecular mechanisms are not well understood. Recently, increasing evidence has reported the importance of the CXCL13-CXCR5 axis in the tumor microenvironment of various human malignancies. Thus, in this review, we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns, regulating and corresponding regulatory mechanisms as well as clinical values in a wide range of human cancers.© The Author(s) 2018. Published by Oxford University Press on behalf of West China School of Medicine & West China Hospital of Sichuan University.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

无

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan.

共同第一作者：

通讯作者：

通讯机构： [4]Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. [5]Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]CXCL13 expression in mouse 4T1 breast cancer microenvironment elicits antitumor immune response by regulating immune cell infiltration. [2]Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration. [3]Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma [4]PD-1+CXCR5-CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma. [5]乳腺癌相关成纤维细胞：乳腺癌治疗的新靶点 [6]Exosome-orchestrated hypoxic tumor microenvironment [7]肿瘤相关的三级淋巴结构的检测和量化分析 [8]肿瘤微环境与免疫治疗研究进展 [9]缺氧肿瘤微环境中外泌体参与免疫调控的研究进展 [10]Reversing chemokine/chemokine receptor mismatch to enhance the antitumor efficacy of CAR-T cells.