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Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment.

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan. [2]The Center of Anesthesiology and Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan. [3]Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan. [4]Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. [5]Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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关键词： chemokine CXCL13 CXCR5 tumor microenvironment

摘要：

Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue. Through interactions between chemokines and their receptors, various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells. In recent decades, a large volume of studies have revealed chemokines' role in the tumor microenvironment in regulating tumor growth, invasion, and/or metastasis as well as tumor immune response; however, their molecular mechanisms are not well understood. Recently, increasing evidence has reported the importance of the CXCL13-CXCR5 axis in the tumor microenvironment of various human malignancies. Thus, in this review, we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns, regulating and corresponding regulatory mechanisms as well as clinical values in a wide range of human cancers.© The Author(s) 2018. Published by Oxford University Press on behalf of West China School of Medicine & West China Hospital of Sichuan University.

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大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan.

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通讯机构： [4]Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. [5]Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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