机构：[1]Department of Nuclear Medicine, 556508The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.[2]Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China.[3]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China.
Asn-Gly-Arg (NGR) motifs have vasculature-homing properties via interactions with the aminopeptidase N (CD13) expressed on tumor neovasculature. Numerous NGR peptides with different molecular scaffolds have been exploited for targeted delivery of different compounds for imaging and therapy. When conjugated with NGR, complexes recognize the CD13 receptor expressed on the tumor vasculature, which improves the specificity to tumor and avoids systematic toxic reactions. Both preclinical and clinical studies performed with these products suggest that NGR-mediated vascular targeting is an effective strategy for delivering bioactive amounts of cytokines to tumor endothelial cells. For molecular imaging, radiolabeled peptides have been the most successful approach and have been translated into clinic. This review describes current data on radiolabeled tumor vasculature-homing NGR peptides for imaging and therapy.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区生化研究方法4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区生化研究方法4 区核医学
第一作者：
第一作者机构：[1]Department of Nuclear Medicine, 556508The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
通讯作者：
通讯机构：[1]Department of Nuclear Medicine, 556508The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.[2]Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China.[3]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China.[*1]Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, No 15 Tai Ping St, Jiangyang District, Luzhou, Sichuan 646000, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhu Liqin,Ding Zhikai,Li Xingliang,et al.Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy.[J].Molecular imaging.2020,19:1536012120934957.doi:10.1177/1536012120934957.
APA：
Zhu Liqin,Ding Zhikai,Li Xingliang,Wei Hongyuan&Chen Yue.(2020).Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy..Molecular imaging,19,
MLA：
Zhu Liqin,et al."Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy.".Molecular imaging 19.(2020):1536012120934957
