机构：[1]Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China[2]Ctr AIDS, STD Control & Prevent, Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China[3]Yibing Ctr Dis Control & Prevent, Yibing, Peoples R China[4]Sichuan Canc Hosp, Acquired Infect Control Dept, Chengdu, Peoples R China[5]Zigong Ctr Dis Control & Prevent, Inspect Dept, Zigong, Peoples R China[6]Sichuan Prov Key Lab Philosophy & Social Sci Intel, Chengdu, Peoples R China
This study aimed to investigate the characteristics of the HIV-1 molecular network among newly diagnosed HIV-infected patients in southern Sichuan City. Plasma samples will be collected from eligible study subjects (n = 1249) during a cross-sectional survey conducted between 2016 and 2020. The HIV-1 polymerase (pol) gene sequences obtained from the collected samples will be used to perform phylogenetic analysis and characterize the genetic subtypes' molecular transmission networks. HIV-1 pol region sequences were successfully amplified in 898 cases, and seven genotypes were obtained, with CRF01_AE (331, 36.86%) and CRF07_BC (368, 40.98%) subtypes as the predominant prevalent strains in the region. 601 sequences entered the molecular transmission network. There were 302 highly connected individuals. Further multivariate analysis showed that the older the age (60-69 years, OR = 1.595, 95% CI: 1.026-2.479; >= 70 years, OR = 2.189, 95% CI: 1.295-3.699), RX and GJ counties (OR = 4.654, 95% CI: 2.776-7.803; OR = 6.847, 95% CI: 3.464-13.533) and CRF08_BC subtype (OR = 2.031, 95% CI: 1.225-3.367) were both more likely to be highly connected individuals. To effectively combat this local HIV-1 epidemic, HIV prevention and intervention programs should target older adults at least 60 years of age and registered residents in districts and counties within RX and GJ.
基金：
Natural Science Foundation of Sichuan Province [2022NSFSC1547]; Joint Fund of Sichuan Collaborative Innovation Center for Aging and Elderly Health [YLKYYB2211]; Chengdu Medical College-Yibin Center for Disease Control and Prevention Joint Research Fund [2021LHYB01, 2023LHYB04]
第一作者机构：[1]Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China[3]Yibing Ctr Dis Control & Prevent, Yibing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China[*1]Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China[2]Ctr AIDS, STD Control & Prevent, Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China[*2]Ctr AIDS, STD Control & Prevent, Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China[*3]Sichuan Prov Key Lab Philosophy & Social Sci Intel, Chengdu, Peoples R China[6]Sichuan Prov Key Lab Philosophy & Social Sci Intel, Chengdu, Peoples R China
推荐引用方式(GB/T 7714)：
Peng Tingchun,Tang Jiayang,Qiu Miaomiao,et al.Characterization of the HIV-1 molecular network in a middle-aged population aged 50 years and older in a City in Southern Sichuan, China[J].SCIENTIFIC REPORTS.2025,15(1):10500.doi:10.1038/s41598-025-95660-0.
APA：
Peng, Tingchun,Tang, Jiayang,Qiu, Miaomiao,Lai, Zhen,Xin, Junguo...&Yang, Xiaohong.(2025).Characterization of the HIV-1 molecular network in a middle-aged population aged 50 years and older in a City in Southern Sichuan, China.SCIENTIFIC REPORTS,15,(1)
MLA：
Peng, Tingchun,et al."Characterization of the HIV-1 molecular network in a middle-aged population aged 50 years and older in a City in Southern Sichuan, China".SCIENTIFIC REPORTS 15..1(2025)
