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Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhao Yue[1] ; Liao Xiongfei[1] ; Wang Yiling[1] ; Lan Wanying[2] ; Ren Jing[3] ; Yang Ningjing[3] ; Li Churong[1] ; Lang Jingyi[1] ; Zhang Shichuan[1,*1] ;
机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China. [2]School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3]Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
出处：
DOI： 10.1016/j.radonc.2022.04.026
ISSN：

关键词： Nasopharyngeal carcinoma Level Ib Clinical target volume PlanIQ

摘要：
To analyze the distribution pattern of lymph nodes (LNs) metastasis of level Ib in nasopharyngeal cancer (NPC) and propose shrinkage of clinical target volume (CTV) boundaries to avoid unnecessary radiation for some space with very low-risk of involvement.Pretreatment images of pathologically proven NPC patients were reviewed and those with positive level Ib LN metastasis was enrolled. The geometric center of each level Ib LN in the neck was marked on a template CT. The spatial relationship of nodes with key structures in level Ib was analyzed. Modified level Ib CTV according to the 2013 International CTV consensus was proposed based on the LN distribution pattern. A PlanIQ Feasibility DVH module was implemented to evaluate the feasibility analysis of the best possible sparing of organs at risk (OAR) with modified Ib CTV.A total of 1518 NPC patients were reviewed and 54 with positive level Ib nodes were enrolled. Four sub-level anatomical regions were defined within the gross area of level Ib. Of 106 positive nodes identified, none, one, 88, and 17 were found in the intraglandular (IG), medial mandibular (MM), supra perivascular (SP), and infra perivascular (IP) sub-level, respectively. This study proposes sparing the IG and MM sub-level and including the area within a specified distance from the submandibular gland (11 mm for SP, 17 mm for IP) for CTV coverage. Compared with planning based on CTV-consensus, planning based on CTV-proposed results in a significantly reduced CTV volume, and mean dose (Dmean) of both the ipsilateral SMG and bilateral SLG.Based on detailed analysis of the relationship between positive node distribution and several important anatomical structures, modified level Ib CTV for prophylactic irradiation was proposed to reduce the dose of OAR irradiation.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China, China (Grant No. 81903135), Sichuan Science and technology Foundation Project, China (Grant No. 2020YJ0454), and National Natural Science Foundation of China, China (Grant No. 61901087).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 2 区 核医学 2 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学 2 区 核医学
JCR分区：
出版当年[2022]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China.
通讯作者：
通讯机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China. [*1]No. 55 Renmin South Road, Chengdu 610041, Sichuan, China.
推荐引用方式(GB/T 7714)：
Zhao Yue,Liao Xiongfei,Wang Yiling,et al.Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy.[J].RADIOTHERAPY AND ONCOLOGY.2022,172:10-17.doi:10.1016/j.radonc.2022.04.026.
APA：
Zhao Yue,Liao Xiongfei,Wang Yiling,Lan Wanying,Ren Jing...&Zhang Shichuan.(2022).Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy..RADIOTHERAPY AND ONCOLOGY,172,
MLA：
Zhao Yue,et al."Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy.".RADIOTHERAPY AND ONCOLOGY 172.(2022):10-17

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