机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Radiation Oncology Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院四川省肿瘤医院[2]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China[3]Department of Oncology, People’s Hospital of Cangxi County, Guangyuan, China[4]Department of Radiation Oncology, Fujian Cancer Center, Fuzhou, China[5]Department of Radiation Oncology, School of Medicine, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China[6]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China[7]Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union University, Beijing, China[8]School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia[9]Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia[10]Australian e-Health Research Centre, CSIRO, Brisbane, QLD, Australia
Purpose The purpose of this study is to investigate the current status of clinical target volume (CTV) delineation for primary site of nasopharyngeal cancer (NPC) among five large tertiary cancer centers in China. Materials and Methods The simulation CT and MR images of a patient with T3N2M0 NPC were sent to the centers participating. Fourteen experienced physicians contoured the targets independently, and the outlined structures were compared. The consistency and differences among these 14 CTVs are discussed. Results Two different CTV designs were used in the centers. "One-CTV" design defines one CTV with a dose of 60 Gy, whereas "two-CTV" design has a high-risk CTV with dose of 60 Gy and a medium risk CTV with dose of 54 Gy. We found that the coverage of prophylactic area is very consistent between these two designs. The variances on the coverage of some sites were also significant among physicians, including covering cavernous sinus at un-involved side, posterior space of styloid process, and caudal border on posterior pharyngeal wall. Conclusions Standardization is the main requirement for personalization of care; our study shows that among the 14 physicians in the five centers the coverage of prophylactic areas is in excellent agreement. Two distinct strategies on CTV design are currently being used, and multiple controversies were found, suggesting further optimization of CTV for primary site of NPC is needed.
基金：
National Natural Science Foundation, ChinaNational Natural Science Foundation of China (NSFC) [81771921]; Science and Technology Bureau of Chengdu City, China [2019-YF09-00095-SN]
第一作者机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Radiation Oncology Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shichuan Zhang,Shuang Yang,Peng Xu,et al.Variations of Clinical Target Volume Delineation for Primary Site of Nasopharyngeal Cancer Among Five Centers in China[J].FRONTIERS IN ONCOLOGY.2020,10:doi:10.3389/fonc.2020.01572.
APA：
Shichuan Zhang,Shuang Yang,Peng Xu,Yun Xu,Guanqun Zhou...&Jinyi Lang.(2020).Variations of Clinical Target Volume Delineation for Primary Site of Nasopharyngeal Cancer Among Five Centers in China.FRONTIERS IN ONCOLOGY,10,
MLA：
Shichuan Zhang,et al."Variations of Clinical Target Volume Delineation for Primary Site of Nasopharyngeal Cancer Among Five Centers in China".FRONTIERS IN ONCOLOGY 10.(2020)
