详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Advances of podophyllotoxin and its derivatives: patterns and mechanisms.

94| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu 610041, Sichuan, China [2]State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu 610041, Sichuan, China [3]Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China

出处：

DOI：

ISSN：

关键词： Podophyllotoxin Anticancer Anti-inflammatory Immunosuppression Antivirals Codelivery nano-drug systems

摘要：

Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyllotoxin derivatives (PPTs) have been synthesized as candidate drugs to improve the pharmacological characteristics of PPT. Nowadays, an increasing number of reviews have summarized structure-optimization, anticancer application, and single nano delivery of PPT and PPTs. In this review, we focus on capturing the multidirectional pharmacological properties of PPT and PPTs, with an emphasis on the crosstalk with anticancer, anti-inflammatory, immunosuppression, and antivirals. Besides, the newly uncovered mechanisms governing PPT and PPTs in pharmacological properties including non-apoptotic regulated cell death are discussed. Moreover, their co-delivery nanocarriers with other antitumor drugs or biological agents that have the potential to achieve increased targeting efficacy are included, thus providing a reference for improving the druggability and expanding the clinical application of podophyllotoxin and its derivatives.Copyright © 2022. Published by Elsevier Inc.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区药学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区药学

JCR分区：

出版当年[2022]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 5.3 最新[2023版] 5.2 最新五年平均 5.8 出版当年[2022版] 5.8 出版当年五年平均 6.1 出版前一年[2021版] 5.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu 610041, Sichuan, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Anti-Inflammatory and Anti-Osteoclastogenesis Activities of Different Kinds of Zanthoxylum bungeanum Seed Oil in Vitro [2]Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons. [3]Repurposing TAK875 as a novel STAT3 inhibitor for treating inflammatory bowel disease [4]抗炎饮食预防肿瘤的专家共识 [5]Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. [6]Synthesis, characterization and biological studies of diosgenyl analogues. [7]Targeting cancer-related inflammation with non-steroidal anti-inflammatory drugs: Perspectives in pharmacogenomics [8]Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer. [9]Evaluation of the Immunomodulatory and Anti-inflammatory Activities of Honey Bee Larva Powder. [10]A battery-free anti-inflammatory brain remote for spatiotemporal guiding movement of mice