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CXCL8 in Tumor Biology and Its Implications for Clinical Translation.

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机构： [1]Department of Urology, National Clinical Research Center for Geriatrics, Institute of Urology, West China Hospital of Sichuan University, Chengdu, China, [2]Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, China, [3]Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China

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关键词： CXCL8 tumor microenvironment tumor progression tumor immune suppression immunotherapy

摘要：

The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor microenvironment (TME) including directly promoting tumor survival and affecting components of TME to indirectly facilitate tumor progression, which include facilitating tumor cell proliferation and epithelial-to-mesenchymal transition (EMT), pro-angiogenesis, and inhibit anti-tumor immunity. More recently, clinical trials indicate that CXCL8 can act as an independently predictive biomarker in patients receiving immune checkpoint inhibitions (ICIs) therapy. Preclinical studies also suggest that combined CXCL8 blockade and ICIs therapy can enhance the anti-tumor efficacy, and several clinical trials are being conducted to evaluate this therapy modality.Copyright © 2022 Xiong, Liao, Qiu, Xu, Zhang, Wang, Ai and Yang.

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出版当年[2022]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学

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第一作者机构： [1]Department of Urology, National Clinical Research Center for Geriatrics, Institute of Urology, West China Hospital of Sichuan University, Chengdu, China,

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