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Dual stimuli-responsive nanocarriers based on polyethylene glycol-mediated schiff base interactions for overcoming tumour chemoresistance.

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资源类型：
Pubmed体系：
作者：
Wei Danfeng[1,4] ; Tong Qiulan[2] ; An Qi[3] ; Ma Xiaomin[2] ; Jiang Xian[1,4,*1] ; Li Xudong[2] ; Yi Zeng[2] ;
机构： [1]Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]National Engineering Research Center for Biomaterials and College of Biomedical Engineering, Sichuan University, Chengdu 610064, PR China [3]Public Health Clinical Center of Chengdu, Chengdu 610041, PR China [4]Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu 610041, PR China
出处：
DOI： 10.1016/j.colsurfb.2022.112408
ISSN：

关键词： Dual-responsive Aminal Reverse drug resistance Mannich-type condensation Enhanced anticancer efficacy

摘要：
Multifunctional and stimulus-sensitive intelligent nanodrug delivery systems (NDDSs) can significantly optimize the effectiveness of theranostic agents for cancer treatment. In this study, redox and pH dual-responsive nanocarriers (CPNPs) were prepared through molecular assembly by utilizing the Schiff base interactions of cystamine (Cys), PEG-NH2 and formaldehyde (FA) under aqueous conditions with a one-pot, one-step technique. First, the degradation products of CPNPs exhibited good biocompatibility, and the high concentration of intact CPNPs (200 µg/mL) could inhibit the growth of cells. In addition, doxorubicin (DOX) was encapsulated in CPNPs simply by changing the pH (DOX@CPNPs), and pH/GSH-responsive release behaviour was confirmed. In vitro, CPNPs significantly increased the uptake of DOX and enhanced the cytotoxicity of DOX to tumour cells. More importantly, DOX@CPNPs strongly reversed drug resistance in three different types of cancer cells, exhibiting significant anticancer effects. Collectively, this study presents the easy preparation of nanomedicines that respond to multiple stimuli, which highlights the advantages of Schiff base-based nanomedicines for cancer therapy and reversing chemoresistance.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
This work was supported by National Natural Science Foundation of China (81602693), China Postdoctoral Science Foundation (2020M673257), Post-Doctor Research Project, West China Hospital, Sichuan University (2020HXBH045) and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC21036).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 工程技术
小类 | 2 区 材料科学：生物材料 2 区 生物物理 2 区 物理化学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 生物物理 2 区 物理化学 3 区 材料科学：生物材料
第一作者：
第一作者机构： [1]Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, PR China [4]Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu 610041, PR China
通讯作者：
通讯机构： [1]Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, PR China [4]Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu 610041, PR China [*1]Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, PR China
推荐引用方式(GB/T 7714)：
Wei Danfeng,Tong Qiulan,An Qi,et al.Dual stimuli-responsive nanocarriers based on polyethylene glycol-mediated schiff base interactions for overcoming tumour chemoresistance.[J].Colloids and surfaces. B, Biointerfaces.2022,213:112408.doi:10.1016/j.colsurfb.2022.112408.
APA：
Wei Danfeng,Tong Qiulan,An Qi,Ma Xiaomin,Jiang Xian...&Yi Zeng.(2022).Dual stimuli-responsive nanocarriers based on polyethylene glycol-mediated schiff base interactions for overcoming tumour chemoresistance..Colloids and surfaces. B, Biointerfaces,213,
MLA：
Wei Danfeng,et al."Dual stimuli-responsive nanocarriers based on polyethylene glycol-mediated schiff base interactions for overcoming tumour chemoresistance.".Colloids and surfaces. B, Biointerfaces 213.(2022):112408

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