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A poly (vinyl alcohol) coated core-shell nanoparticle with a tunable surface for pH and glutathione dual-responsive drug delivery

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机构: [1]College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China [2]Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Monitoring and Evaluation of Rural Land Utilization, Chengdu Normal University, Chengdu 611130, China [3]Joint National Laboratory for Antibody Drug Engineering, Clinical Laboratory of the First Affiliated Hospital, School of Medicine, Henan University, Kaifeng 475004, China [4]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China [5]Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi’an 710021, China [6]Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science and Technology, Xi’an 710021, China
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关键词: Core-shell nanocarriers Poly(vinyl alcohol) Dual-responsive drug delivery Tumor-targeted therapy Boronic ester bond

摘要:
The surface characteristics of nanoparticles play a pivotal role in modulating the efficiency and functionality of drug delivery systems, particularly when addressing the complex challenges of targeted therapeutics. This study presents the development of a core-shell nanoparticle system (PMAA@DOX-PVA), incorporating poly(vinyl alcohol) (PVA) as a dynamic shell component to establish dual responsiveness to pH and glutathione levels. The hydrophilic PVA shell is covalently conjugated to the poly (methylacrylic acid) (PMAA) core via a boronic ester bond, establishing a robust platform for controlled release with tunable surface properties. Notably, our findings demonstrate a remarkable enhancement in drug loading efficiency from a modest 8 % (PMAA@DOX) to an impressive 18 % (PMAA@DOX-PVA-0.2). Furthermore, under physiological conditions (pH 7.4), the drug leakage after 62 hours is significantly reduced, dropping from 37 % (PMAA@DOX) to 21 % (PMAA@DOX-PVA-0.2). This suggests a potential improvement in stability during blood circulation. Intriguingly, the PVA ratio was found to influence drug release profiles under different environments distinctly. The possible mechanism was proposed offering insight into this tunable behavior. In vitro cytotoxicity assays on A549 cancer cells reveal that the blank carriers exhibit excellent biocompatibility, while the PVA-coated nanoparticles significantly boost anti-tumor efficacy. Collectively, these results present a promising strategy for designing core-shell nanoparticles with customizable surface properties, paving the way for next-generation, multifunctional drug delivery systems in diverse biomedical applications.Copyright © 2024 Elsevier B.V. All rights reserved.

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大类 | 2 区 医学
小类 | 1 区 生物物理 2 区 物理化学 3 区 材料科学:生物材料
第一作者:
第一作者机构: [1]College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
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通讯机构: [1]College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China [2]Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Monitoring and Evaluation of Rural Land Utilization, Chengdu Normal University, Chengdu 611130, China
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