详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Polyamine metabolism links gut microbiota and testicular dysfunction.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. [3]Shanwei Institute for Food and Drug Control, Shanwei, Guangdong Province 516622, China. [4]Academician Workstation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. [5]School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China. [6]Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

出处：

DOI：

关键词： Testicular dysfunction Gut microbiota Polyamine metabolism Metabolomics

摘要：

Male fertility impaired by exogenous toxins is a serious worldwide issue threatening the health of the new-born and causing infertility. However, the metabolic connection between toxic exposures and testicular dysfunction remains unclear.In the present study, the metabolic disorder of testicular dysfunction was investigated using triptolide-induced testicular injury in mice. We found that triptolide induced spermine deficiency resulting from disruption of polyamine biosynthesis and uptake in testis, and perturbation of the gut microbiota. Supplementation with exogenous spermine reversed triptolide-induced testicular dysfunction through increasing the expression of genes related to early and late spermatogenic events, as well as increasing the reduced number of offspring. Loss of gut microbiota by antibiotic treatment resulted in depletion of spermine levels in the intestine and potentiation of testicular injury. Testicular dysfunction in triptolide-treated mice was reversed by gut microbial transplantation from untreated mice and supplementation with polyamine-producing Parabacteroides distasonis. The protective effect of spermine during testicular injury was largely dependent on upregulation of heat shock protein 70s (HSP70s) both in vivo and in vitro.The present study linked alterations in the gut microbiota to testicular dysfunction through disruption of polyamine metabolism. The diversity and dynamics of the gut microbiota may be considered as a therapeutic option to prevent male infertility. Video Abstract.© 2021. The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 1 区

生物学

小类 | 1 区微生物学

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区微生物学

第一作者：

第一作者机构： [1]Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

共同第一作者：

通讯作者：

通讯机构： [1]Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Integrated microbiome and metabolomics revealed the protective effect of baicalin on alveolar bone inflammatory resorption in aging [2]Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury [3]Gut microbiota-derived short-chain fatty acids and kidney diseases. [4]Gut and obesity/metabolic disease: Focus on microbiota metabolites [5]Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice. [6]Dietary proanthocyanidins on gastrointestinal health and the interactions with gut microbiota. [7]Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota-brain interactions in colitis [8]Perturbation of Gut Microbiota Modulated the Abscopal Effects of Immunoradiotherapy in Rectal Cancer [9]Lactobacillus johnsonii BS15 Prevents Psychological Stress-Induced Memory Dysfunction in Mice by Modulating the Gut-Brain Axis. [10]Gut microbiota-derived short-chain fatty acids and kidney diseases.