机构：[1]Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China,四川大学华西医院[2]Institute of Digestive Surgery, Institute of General Surgery, West China Hospital, Sichuan University, Chengdu, China,四川大学华西医院[3]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China,四川大学华西医院[4]Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China,四川大学华西医院[5]Department of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院
Colorectal liver metastasis (CRLM) represents a major therapeutic challenge in colorectal cancer (CRC), with complex interactions between the gut microbiota and the liver tumor microenvironment (TME) playing a crucial role in disease progression via the gut-liver axis. The gut barrier serves as a gatekeeper, regulating microbial translocation, which influences liver colonization and metastasis. Through the gut-liver axis, the microbiota actively shapes the TME, where specific microbial species and their metabolites exert dual roles in immune modulation. The immunologically "cold" nature of the liver, combined with the influence of the gut microbiota on liver immunity, complicates effective immunotherapy. However, microbiota-targeted interventions present promising strategies to enhance immunotherapy outcomes by modulating the gut-liver axis. Overall, this review highlights the emerging evidence on the role of the gut microbiota in CRLM and provides insights into the molecular mechanisms driving the dynamic interactions within the gut-liver axis.
基金：
National Natural Science Foundation of China [82003113]
第一作者机构：[1]Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China,[2]Institute of Digestive Surgery, Institute of General Surgery, West China Hospital, Sichuan University, Chengdu, China,
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通讯作者：
推荐引用方式(GB/T 7714)：
Liu Qiu-Luo,Zhou Huijie,Wang Ziqiang,et al.Exploring the role of gut microbiota in colorectal liver metastasis through the gut-liver axis[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2025,13:doi:10.3389/fcell.2025.1563184.
APA：
Liu, Qiu-Luo,Zhou, Huijie,Wang, Ziqiang&Chen, Yan.(2025).Exploring the role of gut microbiota in colorectal liver metastasis through the gut-liver axis.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,13,
MLA：
Liu, Qiu-Luo,et al."Exploring the role of gut microbiota in colorectal liver metastasis through the gut-liver axis".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 13.(2025)
