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Gut microbiota shapes cancer immunotherapy responses

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作者：

机构： [1]Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. [2]Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400037 Chongqing, China. [3]Division of Abdominal Cancer, Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041 ChengDu, Sichuan, China. [4]College of Liberal Arts, Neijiang Normal University, 641100, Neijiang, Sichuan, China. [5]Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.

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摘要：

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.© 2025. The Author(s).

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出版当年[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物 1 区微生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物 1 区微生物学

第一作者：

第一作者机构： [1]Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. [2]Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400037 Chongqing, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. [5]Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.

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