机构：[1]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院[2]Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, China[3]Sichuan Provincial Key Laboratory for Human Disease Gene Study, the Institute of Laboratory Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China四川省人民医院[4]Department of Biomedical Engineering, Columbia University, New York, USA
Although cancer immunotherapy is showing tremendous promise and has progressed to the clinic, it has only achieved sporadic efficacy, with only a fraction of patients benefitting from the therapy and with undesirable side effects due to poor selectivity and high doses. Localized delivery of immunomodulators to activate anticancer immunity in situ avoids overactivation of the systemic immune system and reduces side effects. Engineered biomaterials-implantable, injectable, or transdermal-fabricated into drug delivery devices are critical components for the development of localized cancer immunotherapies. In this review, we briefly summarize progress in the application of engineered biomaterials to the localized delivery of cancer immunotherapy.
基金：
NationalNatural Science Foundation ofChina,
Grant/AwardNumber: 31900988; Science and
Technology Project of Chengdu, Grant/Award
Number: 2019-YF05-00784-SN;KeyResearch
andDevelopment Programof Science and
Technology Department of Sichuan Province,
Grant/AwardNumber: 2019YFS0514;Natural
Science Foundation of Jiangsu Province,
Grant/AwardNumber: SBK2019040088;
Research Funding of Sichuan Provincial
People’s Hospital, Grant/AwardNumber:
2017LY08
第一作者机构：[1]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[2]Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, China[4]Department of Biomedical Engineering, Columbia University, New York, USA[*1]Institute of FunctionalNano &SoftMaterials (FUNSOM), JiangsuKey Laboratory for Carbon-based Functional Materials andDevices, SoochowUniversity, Suzhou, Jiangsu 215123, China.[*2]Department of Biomedical Engineering, ColumbiaUniversity,NewYork, NY, 10027.
推荐引用方式(GB/T 7714)：
Lulu Cai,Jialu Xu,Zhenglin Yang,et al.Engineered biomaterials for cancer immunotherapy[J].MEDCOMM.2020,1(1):35-46.doi:10.1002/mco2.8.
APA：
Lulu Cai,Jialu Xu,Zhenglin Yang,Rongsheng Tong,Ziliang Dong...&Kam W. Leong.(2020).Engineered biomaterials for cancer immunotherapy.MEDCOMM,1,(1)
MLA：
Lulu Cai,et al."Engineered biomaterials for cancer immunotherapy".MEDCOMM 1..1(2020):35-46
