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Improving Cancer Immunotherapy Outcomes Using Biomaterials.

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机构： [1]Department of Chemistry and the N.1 institute for health, National University of Singapore, Singapore, 117543, Singapore. [2]Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, 350207, P. R. China. [3]The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, 330000, P. R. China. [4]State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, No. 17, Section 3, Renmin South Rd., Chengdu, 610041, P. R. China. [5]SZU-NUS Collaborative Center and International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, China.

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Immunotherapy has made great strides in improving clinical outcomes in cancer treatment. However, few patients exhibit adequate response rates for key outcome measures and desired long-term responses, and they often suffer systemic side effects due to the dynamic nature of the immune system. This has motivated a search for alternative strategies to improve unsatisfactory immunotherapeutic outcomes. In recent years, biomaterial-assisted immunotherapy has shown promise in cancer treatment with improved therapeutic efficacy and reduced side effects. These biomaterials have illuminated fundamental mechanisms underlying the immunoediting process, while greatly improving the efficacy of chimeric antigen receptor (CAR) T-cell therapy, cancer vaccine therapy, and immune checkpoint blockade therapy. This Minireview discusses recent advances in engineered biomaterials that address limitations associated with conventional cancer immunotherapies. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2020]版：

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第一作者机构： [1]Department of Chemistry and the N.1 institute for health, National University of Singapore, Singapore, 117543, Singapore.

通讯作者：

通讯机构： [1]Department of Chemistry and the N.1 institute for health, National University of Singapore, Singapore, 117543, Singapore. [2]Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, 350207, P. R. China. [5]SZU-NUS Collaborative Center and International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, China.

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