Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods
机构：[1]Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, China,[2]Department of Clinical Pharmacy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China,临床药学部临床药学部四川省人民医院四川省肿瘤医院[3]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China,四川大学华西医院[4]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, China四川大学华西医院
Introduction:& nbsp;This meta-analysis aims to assess whether the Controlling nutritional status (CONUT) score before treatment can be an independent predictor of the prognosis of patients with urothelial cancer (UC).</p> & nbsp;</p> Methods:& nbsp;The system searches Web of Science, PubMed, MEDLINE, China National Knowledge Infrastructure (CNKI), and Cochrane Library, and the search time is up to April 2021. Use STATA 16.0 and Engauge Digitizer 4.1 software for data processing and statistical analysis.</p> & nbsp;</p> Results:& nbsp;A total of 8 studies were included in this meta-analysis. The meta-analysis results show that compared with the low CONUT group, the high CONUT group has worse over survival (OS) [HR=1.58, 95%CI (1.34, 1.86), P=0.001], cancer-specific survival (CSS) [HR=2.03, 95%CI (1.25-3.29), P=0.04] and recurrence-free survival (RFS) [HR=1.97, 95%CI (1.15, 3.40), P=0.014]; for progression-free survival (PFS), or disease-free survival (DFS), the difference between the two groups was not statistically significant [HR=2.30, 95%CI (0.72, 7.32), P=0.158]. According to different carcinoma types, cut-off value, and region, subgroup analysis of OS was performed, and similar results were obtained.</p> & nbsp;</p> Conclusions:& nbsp;Based on current evidence, this meta-analysis proves that the CONUT score of UC patients before treatment is an independent prognostic predictor. It performs well on OS, CSS, and RFS, but the conclusions on DFS/PFS need to be treated with caution.</p> & nbsp;</p> Systematic Review Registration</p> https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021251890, identifier CRD42021251890.</p>
基金：
Sichuan Province Science and Technology Planning Project [2020YFS0320]; Sichuan Provincial Health Committee Research Project
第一作者机构：[1]Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, China,
共同第一作者：
通讯作者：
通讯机构：[3]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China,[4]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, China
推荐引用方式(GB/T 7714)：
Lei Peng,Chunxiao Du,Chunyang Meng,et al.Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods[J].FRONTIERS IN ONCOLOGY.2021,11:doi:10.3389/fonc.2021.702908.
APA：
Lei Peng,Chunxiao Du,Chunyang Meng,Jinze Li,Chengyu You...&Yunxiang Li.(2021).Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods.FRONTIERS IN ONCOLOGY,11,
MLA：
Lei Peng,et al."Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods".FRONTIERS IN ONCOLOGY 11.(2021)
