The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis.
机构：[1]Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[2]West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院
In recent years, the controlling nutritional status (CONUT) score has increasingly became an effective indicator associated with tumor prognosis. This study was conducted to synthesise data on the prognostic value of CONUT score on patients with upper tract urothelial carcinoma (UTUC) or renal cell carcinoma (RCC) undergoing nephrectomy.We designed and performed a systematic analysis of studies that verified the correlation between preoperative CONUT score and prognosis for UTUC and RCC using PubMed, Web of Science and Embase. The conclusion was clarified by pooled hazard ratios (HR) and 95% confidence intervals (95% CI). Subgroup analysis were further conducted in accordance with different primary tumor.Six studies involving 3529 patients were included in this evidence synthesis, which revealed that the CONUT score had a potential role to predict the survival of UTUC and RCC patients accepting surgery. Pooled analysis showed that the overall survival (OS, HR 2.32, p<0.0001), cancer-special survival (CSS, HR 2.68, p<0.0001) and disease-free survival (DFS, HR 1.62, p<0.00001) were inferior in the high CONUT score group when compared with low score group. Subgroup analysis revealed that this result was in line with UTUC (OS: HR 1.86, P=0.02; CSS: HR 2.24, P=0.01; DFS: HR 1.54, P<0.00001) and RCC (OS: HR 3.05, P<0.00001; CSS: HR 3.47, P<0.00001; DFS: HR 2.21, P=0.0005) patients respectively.The CONUT score is a valuable preoperative index to predict the survival of patients with UTUC or RCC undergoing nephrectomy.
基金：
Key Project of National Natural Science Foundation of China (Grant number: 8177060452).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区营养学
最新[2023]版：
大类|3 区医学
小类|3 区营养学
第一作者：
第一作者机构：[1]Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[2]West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Urology, Institute of urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.[*1]Department of Urology, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan, P.R. China. Post Code: 610041,
推荐引用方式(GB/T 7714)：
Chen Junhao,Cao Dehong,Peng Zhufeng,et al.The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis.[J].The British journal of nutrition.2021,1-20.doi:10.1017/S0007114521002889.
APA：
Chen Junhao,Cao Dehong,Peng Zhufeng,Song Pan,Liu Zhenghuan...&Dong Qiang.(2021).The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis..The British journal of nutrition,,
MLA：
Chen Junhao,et al."The prognostic value of the controlling nutritional status (CONUT) score on patients undergoing nephrectomy for upper tract urothelial carcinoma or renal cell carcinoma: a systematic review and meta-analysis.".The British journal of nutrition .(2021):1-20
