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Predictive value of preoperative lymphocyte-to-monocyte ratio for patients with upper tract urothelial carcinoma.

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机构： [1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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关键词： Lymphocyte-to-monocyte ratio Upper tract urothelial carcinoma Prognostic value

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To determine the predictive value of preoperative lymphocyte-to-monocyte ratio (LMR) for pathological and survival outcomes in upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). This retrospective study included 704 UTUC patients between 2008 and 2017. We used a cutoff LMR of 3.6 to evaluate its relationship with oncological outcomes after RNU, using the Kaplan-Meier method and logistic regression models. During median follow-up of 39 months, decreased preoperative LMR was an independent predictor of poor pathological outcomes. Kaplan-Meier analysis revealed that patients with low LMR (<3.6) had poor cancer-specific survival (CSS), recurrence-free survival (RFS), and overall survival (OS); this prognostic value was ascertained for patients with high pathological grade and more advanced stage UTUC, but not for patients with low pathological features. Multivariate Cox proportional hazards model revealed that low LMR was an independent predictor of poor CSS, RFS and OS [hazard ratio (HR) = 1.42, P = 0.02; HR = 1.39, P = 0.008; HR = 1.38, P = 0.017, respectively]. Preoperative low LMR was an independent predictor of poor pathological and oncological outcomes of UTUC after RNU. Subgroup analysis confirmed that the prognostic value of LMR was confined to patients with a high pathological grade and more advanced stage tumor. Copyright © 2019 Elsevier B.V. All rights reserved.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

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第一作者机构： [1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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通讯机构： [1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China [*1]Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Number 37, Guoxue Alley, Chengdu, Sichuan 610041, China

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