机构：[1]School of Clinical Medicine, Southwest Medical University, Luzhou, China[2]Department of Clinical Laboratory, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu, China四川省肿瘤医院[3]Department of Clinical Laboratory, The First People’s Hospital of Yibin, Yibin, China[4]Department of Clinical Laboratory, Chengdu Fifth People’s Hospital, Chengdu, China[5]Department of Clinical Laboratory, Zigong First People’s Hospital, Zigong, China[6]Department of Clinical Laboratory, People’s Hospital of Jianyang city, Jianyang, China[7]School of Basic Medicine, Fourth Military Medical University, Xian, China
Background It has been widely reported that the prognostic nutritional index (PNI) played a pivotal role in nutritional assessment of surgical patients and tumor prognosis. In order to improve the accuracy of evaluation in Western China, we established reference intervals (RIs) of PNI in healthy controls. Methods A retrospective cohort study on healthy ethnic Han adults (18-79 years) was conducted to explore the influences of age, gender, study centers, and instruments on PNI and to establish RIs. The data came from a healthy routine examination center database and laboratory information system (LIS) of four centers in Western China, and there were 200 persons selected randomly for verification of RIs. Results Five thousand eight hundred and thirty-nine healthy candidates were enrolled. PNI showed a marked gender dependence, and males had significantly higher PNI than females across all ages (p < 0.01). We found that PNI is significantly different between age groups (p < 0.01), the value of PNI tended to decrease with age increasing. There is also an obvious influence of centers and instruments on PNI (p < 0.01). Conclusions We established reference intervals of PNI in healthy Han Chinese population in Western China and validated successfully. Further established RIs will lead to better standardizations of PNI for clinical applications.
基金：
Health and Family Planning Commission of
Sichuan Province universal application
project (No.20PJ115) and the Science
and Technology Bureau of Chengdu
technological innovation project (NO.
2019-YF05-01279-SN)
第一作者机构：[1]School of Clinical Medicine, Southwest Medical University, Luzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Clinical Medicine, Southwest Medical University, Luzhou, China[2]Department of Clinical Laboratory, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu, China[7]School of Basic Medicine, Fourth Military Medical University, Xian, China[*1]School of Basic Medicine, Fourth Military Medical University, No. 169 Changle West Rd, Xi’an 710032, Xian, China.[*2]School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China, No. 1, Section 1, Xiang Lin Road, Luzhou 646000, Sichuan, China.[*3]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, School of Medicine, University of Electronic Science and Technology of China, No 55, Section 4, South People’s Road, Chengdu 610041, Sichuan, China.
推荐引用方式(GB/T 7714)：
Yang Guishu,Wang Dongsheng,He Linbo,et al.Normal reference intervals of prognostic nutritional index in healthy adults: A large multi-center observational study from Western China[J].JOURNAL OF CLINICAL LABORATORY ANALYSIS.2021,35(7):doi:10.1002/jcla.23830.
APA：
Yang, Guishu,Wang, Dongsheng,He, Linbo,Zhang, Guangjie,Yu, Jianhong...&Luo, Huaichao.(2021).Normal reference intervals of prognostic nutritional index in healthy adults: A large multi-center observational study from Western China.JOURNAL OF CLINICAL LABORATORY ANALYSIS,35,(7)
MLA：
Yang, Guishu,et al."Normal reference intervals of prognostic nutritional index in healthy adults: A large multi-center observational study from Western China".JOURNAL OF CLINICAL LABORATORY ANALYSIS 35..7(2021)
