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Clinical significance of prognostic nutritional index in renal cell carcinomas.

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收录情况： ◇ SCIE ◇ 预警期刊

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机构： [1]Department of Pediatric Surgery, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [3]Department of Urology, Fujian Province Hospital, NO.134 East Street, Fuzhou, Fujian, China. [4]Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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关键词： overall survival prognostic nutritional index recurrence-free survival renal cell carcinoma

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Prognostic nutritional index (PNI) could reflect the nutrition and inflammation status in cancer patients. This study aims to identify the prognostic significance of PNI in patients with renal cell carcinoma (RCC).A total of 694 RCC patients from our institution were included in this study. The prognostic correlation between PNI and overall survival (OS) and recurrence-free survival (RFS) was analyzed respectively using Kaplan-Meier method and univariate and multivariate Cox model. Studies about the association between pretreatment or preoperative PNI and prognosis of RCC were systemically reviewed and a meta-analysis method was performed to further evaluate the pooled prognostic value of PNI in RCC.267 (38.47%) RCC patients had low PNI according to the cut off value (49.08). Low PNI was associated with poor OS (P < .001) and RFS (P < .001), respectively. In the multivariate Cox analysis, PNI was identified to be an independent prognostic factor for OS (hazard ratio [HR] = 2.13, 95%CI: 1.25-3.62, P = .005). Compared to other nutritional indexes, this risk correlation of PNI is better than that of geriatric nutritional risk index (GNRI; HR = 1.19; P = .531), while is no better than that of neutrophil-lymphocyte ratio (NLR; 1/HR = 2.56; P < .001) and platelet-lymphocyte ratio (PLR; 1/HR = 2.85; P < .001) respectively. Meanwhile, additional 4785 patients from 6 studies were included into pooled analysis. For RCC patients who underwent surgery, low preoperative PNI was significantly associated with worse OS (pooled HR = 1.57, 95%CI: 1.37-1.80, P < .001) and worse RFS (pooled HR = 1.69, 95%CI: 1.45-1.96, P < .001). Furthermore, low PNI (<41-51) was also significantly associated with poor OS (HR = 1.78, 95%CI: 1.26-2.53 P < .05) and poor RFS (HR = 2.03, 95%CI: 1.40-2.95, P < .05) in advanced cases treated with targeted therapies.The present evidences show that PNI is an independent prognostic factor in RCC. Low PNI is significant associated with poor prognosis of RCC patients. Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区医学：内科

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：内科

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出版当年[2021]版：

Q3 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

影响因子： 1.3 最新[2023版] 1.6 最新五年平均 1.817 出版当年[2021版] 2.227 出版当年五年平均 1.889 出版前一年[2020版] 1.6 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Pediatric Surgery, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

通讯作者：

通讯机构： [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

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Clinical significance of prognostic nutritional index in renal cell carcinomas.

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