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Impact of the preoperative prognostic nutritional index on survival outcomes in upper tract urothelial carcinomas.

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机构: [1]Department of Urology & Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
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关键词: albumin lymphocyte prognostic nutritional index radical nephroureterectomy upper tract urothelial carcinoma

摘要:
To investigate the value of prognostic nutritional index (PNI) in patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU). A total of 717 patients were included in our study from 2003 to 2016. PNI was calculated as 10 × serum albumin level (g/dL) + 0.005 × total lymphocyte count (per mm3 ). Kaplan-Meier analysis and Cox regression models were adapted to analyze the value of PNI on survival outcomes. The cutoff value of PNI was set as 46.91 and 298 patients (47.6%) had PNI <46.91. The median follow-up was 50 months. The results suggested that low PNI was significantly associated with worse pathologic features (all P < 0.001). Multivariable Cox regression analysis revealed that PNI < 46.91 was an independent predictor of poor overall survival (Hazard ratios [HR] = 1.777, 95% CI = 1.383-2.284, P < 0.001), cancer-specific survival (HR = 1.850, 95% CI = 1.399-2.445, P < 0.001), and recurrence-free survival (HR = 1.554, 95% CI = 1.229-1.964, P < 0.001). Low preoperative PNI was associated with worse survival outcomes in patients with UTUC. PNI could be an easily assessed blood-based biomarker to predict the prognosis in patients with UTUC treated with RNU. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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出版当年[2019]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
第一作者:
第一作者机构: [1]Department of Urology & Institute of Urology, West China Hospital, Sichuan University, Chengdu, China
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通讯机构: [1]Department of Urology & Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [*1]Department of Urology & Institute of Urology, West China Hospital, Sichuan University, Number 37, Guoxue Alley, Chengdu, Sichuan 610041, China.
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