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Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma.

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收录情况： ◇ SCIE

作者：
Zhu Guiquan[1,*1] * ; Cao Bangrong[2] ; Liang Xinhua[1] ; Li Longjiang[1] ; Hao Yaying[2] ; Meng Wanrong[2] ; He Chuanshi[2] ; Wang Linlin[2] ; Li Ling[2,*2] ;
机构： [1]Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Centre for OralDiseases, Sichuan University, 610041, Chengdu, China [2]Sichuan Key Laboratory of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science andTechnology of China, 610041, Chengdu, China
出处：
DOI： 10.1016/j.canlet.2021.01.006
ISSN：

关键词： Small extracellular vesicle miR-192/215 Cancer associated fibroblast Hypoxia Head and neck squamous cell carcinoma

摘要：
The mechanisms underlying the hypoxic cancer cell-mediated differentiation of cancer-associated fibroblasts (CAFs) have not been elucidated yet. The present study showed that the hypoxic head and neck squamous cell carcinoma (HNSCC) cells promoted CAF-like differentiation through secreting TGF-β and small extracellular vesicles (sEVs) that contain enhanced levels of miR-192/215 family miRNAs. Caveolin-1 (CAV1), which is a target gene of miR-192/215, inhibited the TGF-β/SMAD signaling and promoted CAF-like differentiation of the fibroblasts. Restoring the levels of CAV1 inhibited the hypoxic sEV- and TGF-β-induced CAF-like differentiation. The enhanced levels of miR-192/215 encapsulated in the HNSCC tissue-derived sEVs (but not serum-derived sEVs) indicated hypoxic and aggressive cancer stroma. miR-215 in the tumor tissue-derived sEVs (but not circulating sEVs) was correlated with poor overall survival of patients with HNSCC. This study demonstrated that sEVs function as a "courier" to deliver miRNAs from the cancer cells to the fibroblasts, which promotes the remodeling of the hypoxic tumor microenvironment, and that cancer tissue-derived sEV could potentially serve as a source of biomarker. Copyright © 2021. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (grant No. 81972541, 81872196, 81772900, and 81672690) and the Department of Science and Technology of Sichuan Province (grant No. 2020ZYD033)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2021]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Centre for OralDiseases, Sichuan University, 610041, Chengdu, China [*1]Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, 610041, Chengdu, Sichuan, PR China
通讯作者：
通讯机构： [1]Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Centre for OralDiseases, Sichuan University, 610041, Chengdu, China [2]Sichuan Key Laboratory of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science andTechnology of China, 610041, Chengdu, China [*1]Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, 610041, Chengdu, Sichuan, PR China [*2]Sichuan Key Laboratory of Radiation Oncology, Sichuan Cancer Hospital, No. 55, Section 4, Renmin South Road, 610041, Chengdu, Sichuan, PR China
推荐引用方式(GB/T 7714)：
Zhu Guiquan,Cao Bangrong,Liang Xinhua,et al.Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma.[J].CANCER LETTERS.2021,506:11-22.doi:10.1016/j.canlet.2021.01.006.
APA：
Zhu Guiquan,Cao Bangrong,Liang Xinhua,Li Longjiang,Hao Yaying...&Li Ling.(2021).Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma..CANCER LETTERS,506,
MLA：
Zhu Guiquan,et al."Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma.".CANCER LETTERS 506.(2021):11-22

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