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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study

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收录情况： ◇ SCIE ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
ZHU Yuan Yue[1,2] * ; ZHENG Rui Zhi[1,2] * ; WANG Gui Xia[3] * ; CHEN Li[4] * ; SHI Li Xin[5] ; SU Qing[6] ; XU Min[1,2] ; XU Yu[1,2] ; CHEN Yu Hong[1,2] ; YU Xue Feng[7] ; YAN Li[8] ; WANG Tian Ge[1,2] ; ZHAO Zhi Yun[1,2] ; QIN Gui Jun[9] ; WAN Qin[10] ; CHEN Gang[11] ; GAO Zheng Nan[12] ; SHEN Fei Xia[13] ; LUO Zuo Jie[14] ; QIN Ying Fen[14] ; HUO Ya Nan[15] ; LI Qiang[16] ; YE Zhen[17] ; ZHANG Yin Fei[18] ; LIU Chao[19] ; WANG You Min[20] ; WU Sheng Li[21] ; YANG Tao[22] ; DENG Hua Cong[23] ; ZHAO Jia Jun[24] ; CHEN Lu Lu[25] ; MU Yi Ming[26] ; TANG Xu Lei[27] ; HU Ru Ying[17] ; WANG Wei Qing[1,2] ; NING Guang[1,2] ; LI Mian[1,2] ; LU Jie Li[1,2] ; BI Yu Fang[1,2] ;
机构： [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [2]Shanghai NationalClinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of theNational Health Commission of the PR China, Shanghai National Center for Translational Medicine, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [3]The First Hospital of JilinUniversity, Changchun 130021, Jinlin, China [4]Qilu Hospital of Shandong University, Jinan 250012, Shandong,China [5]Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China [6]Xinhua HospitalAffiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China [7]Tongji Hospital, TongjiMedical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China [8]Sun Yat-senMemorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China [9]The First Affiliated Hospitalof Zhengzhou University, Zhengzhou 450052, Henan, China [10]The Affiliated Hospital of Southwest MedicalUniversity, Luzhou 646099, Sichuan, China [11]Fujian Provincial Hospital, Fujian Medical University, Fuzhou350001, Fujian, China [12]Dalian Municipal Central Hospital, Dalian 116003, Liaoning, China [13]The FirstAffiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China [14]The First AffiliatedHospital of Guangxi Medical University, Nanning 530021, Guangxi, China [15]Jiangxi Provincial People’s HospitalAffiliated to Nanchang University, Nanchang 330006, Jiangxi, China [16]The Second Affiliated Hospital of HarbinMedical University, Harbin 150086, Heilongjiang, China [17]Zhejiang Provincial Center for Disease Control andPrevention, Hangzhou 310051, Zhejiang, China [18]Central Hospital of Shanghai Jiading District, Shanghai201800, China [19]Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028,Jiangsu, China [20]The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China [21]Karamay Municipal People’s Hospital, Karamay 830054, Xinjiang, China [22]The First Affiliated Hospital ofNanjing Medical University, Nanjing 210029, Jiangsu, China [23]The First Affiliated Hospital of ChongqingMedical University, Chongqing 400016, China [24]Shandong Provincial Hospital affiliated to Shandong University,Jinan 250021, Shandong, China [25]Union Hospital, Tongji Medical College, Huazhong University of Science andTechnology, Wuhan 430022, Hubei, China [26]Chinese People’s Liberation Army General Hospital, Beijing 100853,China [27]The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
出处：
DOI： 10.3967/bes2021.003
ISSN：

关键词： Cross-sectional study Glycemic index Glycemic status Serum uric acid

摘要：
Objective: The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population. Methods: The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models. Results: A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices). Conclusion: An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women. © 2021 The Editorial Board of Biomedical and Environmental Sciences

基金：
This work is supported by grants from the Ministry of Science and Technology of the People's Republic of China [grant nos. 2016YFC1305600, 2016YFC1305202, 2016YFC1304904, 2017YFC1310700, and 2018YFC1311800]; the National Natural Science Foundation of China [grant nos. 81970706, 81970691, 81970728, and 81800683].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 公共卫生、环境卫生与职业卫生 3 区 环境科学
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 环境科学 4 区 公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2021]版：
Q3 ENVIRONMENTAL SCIENCES Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q2 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [2]Shanghai NationalClinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of theNational Health Commission of the PR China, Shanghai National Center for Translational Medicine, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China [2]Shanghai NationalClinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of theNational Health Commission of the PR China, Shanghai National Center for Translational Medicine, RuijinHospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
推荐引用方式(GB/T 7714)：
ZHU Yuan Yue,ZHENG Rui Zhi,WANG Gui Xia,et al.Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study[J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES.2021,34(1):9-+.doi:10.3967/bes2021.003.
APA：
ZHU Yuan Yue,ZHENG Rui Zhi,WANG Gui Xia,CHEN Li,SHI Li Xin...&BI Yu Fang.(2021).Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,34,(1)
MLA：
ZHU Yuan Yue,et al."Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 34..1(2021):9-+

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