机构：[1]Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;临床科室其他部门放疗科华南肿瘤学国家重点实验室中山大学肿瘤防治中心[2]Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou, Guangdong, Peoples R China
Background. The purpose of this study was to determine the predictive value of pretreatment serum uric acid (SUA) for metastasis in locally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy. Methods. This retrospective study examined 1063 patients with locally advanced NPC. Multivariate survival analysis was used. Results. High pretreatment SUA level (>353.4 mu mol/L) independently predicted distant metastasis-free survival (p = .013) and was associated with high white blood cell (p = .005), lymphocyte counts (p < .001), and male sex (p < 0.001). In addition, SUA levels were significantly elevated in patients with T1 to T3 classification (p = .042). For patients with subsequent lung metastases after treatment, markedly higher pretreatment SUA levels were detected compared with patients who had other distant metastases (p = .012) and patients without distant metastasis (p = .024). Conclusion. Pretreatment SUA may be a useful biomarker for evaluating treatment options for patients with locally advanced NPC. (C) 2016 Wiley Periodicals, Inc.
基金：
Health and Medical Collaborative Innovation Project of Guangzhou City of China [201400000001]; National Science and Technology Pillar Program during the Twelfth Five-year Plan Period [2014BAI09B10]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|1 区耳鼻喉科学3 区外科
最新[2023]版：
大类|3 区医学
小类|3 区耳鼻喉科学3 区外科
第一作者：
第一作者机构：[1]Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
Du Xiao-Jing,Chen Lei,Li Wen-Fei,et al.Use of pretreatment serum uric acid level to predict metastasis in locally advanced nasopharyngeal carcinoma[J].HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK.2017,39(3):492-497.doi:10.1002/hed.24631.
APA：
Du, Xiao-Jing,Chen, Lei,Li, Wen-Fei,Tang, Ling-Long,Mao, Yan-Ping...&Ma, Jun.(2017).Use of pretreatment serum uric acid level to predict metastasis in locally advanced nasopharyngeal carcinoma.HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,39,(3)
MLA：
Du, Xiao-Jing,et al."Use of pretreatment serum uric acid level to predict metastasis in locally advanced nasopharyngeal carcinoma".HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 39..3(2017):492-497
医学