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Radical resection versus local excision for low rectal gastrointestinal stromal tumor: A multicenter propensity score-matched analysis

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收录情况： ◇ SCIE

作者：
Wang, T[a] * ; Zhao, Y[b] * ; Wang, M[c] ; Zhang, P[a] ; Lin, G[d] ; Liu, Q[e] ; Feng, F[f] ; Xiong, Z[g] ; Hu, J[h] ; Zhang, B[i] ; Ye, Y[j,*c] ; Xia, L[k,*b] ; Tao, K[a,*1] ;
机构： [a]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [b]Department of Gastric Surgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, China [c]Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [d]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China [e]Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of MedicalSciences and Peking Union College, Beijing, China [f]Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, China [g]Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [h]Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [i]Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China [j]Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, China [k]Department of General Surgery, the First Affiliated Hospital of Shandong First Medical University, Jinan, China [*a]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
出处：
DOI： 10.1016/j.ejso.2021.01.027
ISSN：

关键词： Gastrointestinal stromal tumor Propensity score matching Rectum Surgery

摘要：
Background: The surgical approaches and resection extent for rectal gastrointestinal stromal tumors (GISTs) are controversial due to the low incidence of this disease. A multicenter retrospective cohort study was conducted to compare the postoperative and oncologic outcomes of local excision (LE) and radical resection (RR) in patients with low rectal GIST. Patients and methods: The medical records of rectal GIST patients from 11 large-scale medical centers in China (January 2000-December 2019) were reviewed. All patients were divided into either the LE group or the RR group. Propensity score matching (PSM) was conducted to reduce confounders. Results: A total of 280 patients with low rectal GIST were enrolled. After PSM, 144 patients were included (72 in each group). The LE group showed a higher anal preservation rate (100.0% vs. 76.4%, P < 0.001), shorter operation time (77.1 ± 68.4 min vs. 159.1 ± 83.6 min, P < 0.001), fewer complications (8.3% vs. 22.2%, P = 0.021) and shorter postoperative hospital stay (4.9 ± 4.1 d vs. 10.7 ± 8.1 d, P < 0.001) than the RR group. There was no significant difference in recurrence-free survival (RFS) between the RR and LE groups among patients with tumors ≤2 cm (P = 0.220), and the RR group had a superior RFS than the LE group in patients with tumors >2 cm (P = 0.046). Conclusions: LE resulted in improved postoperative outcomes and comparable oncological safety with a low rectal GIST of ≤2 cm. However, for patients with a low rectal GIST of >2 cm, RR might be a more appropriate option with better RFS. © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology

基金：
This study was funded by the National Natural Science Foundation of China (grant numbers 81702386 and 81874184 ).
语种：
外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 外科 3 区 肿瘤学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学 2 区 外科
JCR分区：
出版当年[2021]版：
Q1 SURGERY Q3 ONCOLOGY
最新[2023]版：
Q1 SURGERY Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [j]Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, China [k]Department of General Surgery, the First Affiliated Hospital of Shandong First Medical University, Jinan, China [*a]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China [*b]Department of General Surgery, the First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China [*c]Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, 100044, China
推荐引用方式(GB/T 7714)：
Wang T,Zhao Y,Wang M,et al.Radical resection versus local excision for low rectal gastrointestinal stromal tumor: A multicenter propensity score-matched analysis[J].EJSO.2021,47(7):1668-1674.doi:10.1016/j.ejso.2021.01.027.
APA：
Wang, T,Zhao, Y,Wang, M,Zhang, P,Lin, G...&Tao, K.(2021).Radical resection versus local excision for low rectal gastrointestinal stromal tumor: A multicenter propensity score-matched analysis.EJSO,47,(7)
MLA：
Wang, T,et al."Radical resection versus local excision for low rectal gastrointestinal stromal tumor: A multicenter propensity score-matched analysis".EJSO 47..7(2021):1668-1674

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