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Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis

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资源类型：
Pubmed体系：
作者：
Jiang Xiaomei[1] * ; Zhou Hang[1,2] ; Zheng Zhaoyang[1] ; Wang Xiaodong[1] ; Zhou Zongguang[3] ; Yang Lie[1,3] ;
机构： [1]Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital of Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China [2]Department of General Surgery, Jiujiang First People’s Hospital, No.48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi, China [3]Institute of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
出处：
DOI： 10.1007/s13304-025-02452-2
ISSN：

关键词： Laparoscopic resection T4 colon cancer Safety Oncological outcomes

摘要：
The suitability of laparoscopy for T4 colon cancer (CC) remains controversial. This study aims to compare the short-term and long-term oncological outcomes specifically for T4 CC.This observational study included patients who underwent either laparoscopic resection (LR) or open resection (OR) for T4 CC (2015-2023). Propensity score matching (PSM) was used to balance covariates (age, sex, BMI, ASA classification and tumor staging). Primary outcomes were 3-year overall survival (OS) and disease-free survival (DFS). Secondary endpoints included postoperative outcomes and recurrence rates. Prognostic factors for OS and DFS were also analyzed and results of the logistic regression analyses were presented as hazard ratios (HR) with 95 confidence intervals (CI).A total of 176 patients were enrolled, with 75 well-balanced pairs after PSM. The LR group demonstrated comparable major complication rates to the OR group (8.0% vs. 5.3%, P = 0.734). During a mean follow-up of 44.1 ± 28.1 months after LR versus 40.8 ± 23.6 months after OR (P = 0.960), postoperative recurrence rates were similar (LR: 24.0% vs. OR: 17.3%, P = 0.550). The 3-year OS rates were 76.8% and 81.9% in LR and OR respectively (P = 0.292), and 3-year DFS rates were 68.6% and 71.7% in LR and OR, respectively (P = 0.312). Multivariate cox regression analysis determined significant independent predictors for OS included age > 75 years (HR = 11.03, 95%CI 5.29-22.98, P < 0.001), adjuvant therapy (HR = 0.45, 95%CI 0.23-0.87, P = 0.017) and positive lymph nodes (HR = 1.12 per node, 95%CI 1.01-1.25, P = 0.035). Key determinants including age > 75 years (HR = 7.25, 95%CI 3.70-14.20, P < 0.001), adjuvant therapy (HR = 0.29, 95%CI 0.16-0.53, P < 0.001), AJCC staging (III vs. Ⅱ: HR = 2.56, 95%CI 1.07-6.12, P = 0.034) and excised lymph nodes (HR = 1.05 per node, 95%CI 1.02-1.07, P = 0.001) were indepently associated with DFS.LR demonstrates comparable short-term and long-term oncological outcomes to OR and it should be considered as a safe and feasible option for T4 CC.© 2025. The Author(s).

基金：
his research was supported by the 1·3·5 Project for Disciplines of Excellence - Clinical Research Incubation Project, West China Hospital, Sichuan University (Grant Number: 2022HXFH028).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 医学
小类 | 3 区 外科
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 外科
第一作者：
第一作者机构： [1]Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital of Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China
通讯作者：
通讯机构： [1]Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital of Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan, China [3]Institute of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
推荐引用方式(GB/T 7714)：
Jiang Xiaomei,Zhou Hang,Zheng Zhaoyang,et al.Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis[J].Updates In Surgery.2025,doi:10.1007/s13304-025-02452-2.
APA：
Jiang Xiaomei,Zhou Hang,Zheng Zhaoyang,Wang Xiaodong,Zhou Zongguang&Yang Lie.(2025).Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis.Updates In Surgery,,
MLA：
Jiang Xiaomei,et al."Laparoscopic surgery should be a viable option for T4 colon cancer: evidence from a propensity score matching analysis".Updates In Surgery .(2025)

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