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Is lymph node metastasis an advanced event of gastrointestinal stromal tumor?

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收录情况： ◇ SCIE

作者：
Jiang Qi[1] * ; Zhang Peng[1] * ; Yang Weili[2] * ; Gao Xiaodong[3] ; Fu Yingfeng[4] ; Zhang Jun[5] ; Zhang Bo[6] ; Feng Fan[7] ; Zhai Gang[8] ; Fu Yang[9] ; Wu Xin[10] ; Zhang Xinhua[11] ; Wu Xiaojun[12] ; Gao Zhidong[13] ; Liang Han[14] ; Zhou Yanbing[15] ; Liu Heli[16,*1] ; Tao Kaixiong[1,*2] ;
机构： [1]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [2]Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. [3]Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. [4]Department of Gastrointestinal Surgery, Taihe Hospital of Hubei University of Medicine, Shiyan, 442000, China. [5]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. [6]Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. [7]Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Air Force Medical University, Xi'an, 710032, China. [8]Department of General Surgery, Shanxi Province Cancer Hospital(Shanxi Cancer institute), Taiyuan, 030013, China. [9]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [10]Department of General Surgical Medicine, The First Medicine Center of PLA General Hospital, Beijing, 100853, China. [11]Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. [12]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. [13]Department of Gastrointestinal Surgery, Peking University People's Hospital, Peking University, Beijing, 100044, China. [14]Department of Gastric Cancer Center, Tianjin Medical University, Cancer Institute & Hospital, Tianjin, 300060, China. [15]Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, 266003, China. [16]Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
出处：
DOI： 10.1093/oncolo/oyaf351
ISSN：

关键词： gastrointestinal stromal tumor lymph node metastasis propensity score matching outcome

摘要：
The clinicopathological features and outcome of gastrointestinal stromal tumors (GISTs) with lymph node metastasis remain controversial owing to their low incidence. A multicenter retrospective cohort study was conducted to compare the clinicopathological features and oncologic outcomes of GIST without metastasis, with lymph node metastasis and with distant metastasis.The medical records of patients with GISTs in 16 large medical centers in China from January 2014 to December 2022 were reviewed. Patients were divided into four groups: no metastasis (988 cases, 89.1%), lymph node metastasis without distant metastasis (75 cases, 6.8%), distant metastasis without lymph node metastasis (36 cases, 3.2%), and distant metastasis with lymph node metastasis group (10 cases, 0.9%). Propensity score matching (PSM) was performed to reduce confounding factors.A total of 1109 cases of primary GIST were included in this study, comprising 607 males (54.7%) and 502 females (45.3%), with a mean age of 56.6 ± 11.9 years. Compared to that in GIST without lymph node metastasis, the proportion of non-gastric GIST was higher in GIST with lymph node metastasis (52.9% vs. 40.7%) with a larger tumor diameter (>10 cm: 36.5% vs. 18.1%) and more patients with distant metastasis (11.8% vs. 3.5%). Tumor location not in the stomach, the largest tumor diameter, and distant metastasis were independent risk factors for GIST with lymph node metastasis (all P < 0.05). After PSM, 96, 48, 24 patients comprised no metastasis, lymph node metastasis without distant metastasis, and distant metastasis without lymph node metastasis, respectively. The relapse-free survival (RFS) of the lymph node metastasis group was comparable to that of the distant metastasis group without lymph node metastasis (P = 0.368) and significantly inferior to that of no metastases (P = 0.042).The RFS of patients with GIST with lymph node metastasis was comparable to those with distant metastasis and significantly worse than those without metastasis. Lymph node metastasis is an advanced event in GIST.© The Author(s) 2025. Published by Oxford University Press.

基金：
This work was supported by the National Natural Science Foundation of China (grant numbers 81702386, 81874184, and 82072736)
语种：
外文
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出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
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出版当年[2024]版：
Q2 ONCOLOGY
最新[2024]版：
Q2 ONCOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [16]Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. [*1]Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China [*2]Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
推荐引用方式(GB/T 7714)：
Jiang Qi,Zhang Peng,Yang Weili,et al.Is lymph node metastasis an advanced event of gastrointestinal stromal tumor?[J].The Oncologist.2025,30(11):doi:10.1093/oncolo/oyaf351.
APA：
Jiang Qi,Zhang Peng,Yang Weili,Gao Xiaodong,Fu Yingfeng...&Tao Kaixiong.(2025).Is lymph node metastasis an advanced event of gastrointestinal stromal tumor?.The Oncologist,30,(11)
MLA：
Jiang Qi,et al."Is lymph node metastasis an advanced event of gastrointestinal stromal tumor?".The Oncologist 30..11(2025)

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