机构：[1]Department of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, People’s Republic of China[2]Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, People’s Republic of China[3]Department of Colorectal Surgery, Qilu Hospital of Shandong University (Qingdao), Qingdao 266035, Shandong, People’s Republic of China[4]Department of Gastrointestinal Surgery, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, People’s Republic of China[5]Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China重庆医科大学附属第一医院[6]Department of General Surgery, Zigong First People’s Hospital, Zigong 643000, Sichuan, People’s Republic of China[7]Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People’s Republic of China[8]Department of Gastric and Colorectal Surgery, The First Hospital of Jilin University, Changchun, 130021 Jilin, People’s Republic of China[9]Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, People’s Republic of China[10]Department of Colorectal-Anal Surgery, Third Hospital of Jilin University and Bethune Hospital, Changchun, 130033 Jilin, People’s Republic of China[11]Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, People’s Republic of China[12]Department of Gastrointestinal Surgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, People’s Republic of China[13]Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, People’s Republic of China大连医科大学附属第一医院[14]Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China[15]Department of Colorectal Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, People’s Republic of China中国医科大学附属盛京医院中国医科大学盛京医院[16]Department of Gastrointestinal Surgery, Qinghai University Affiliated Hospital, Xining 810000, Qinghai, People’s Republic of China[17]Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China[18]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People’s Republic of China首都医科大学附属北京友谊医院[19]Department of General Surgery, Dongguan Kanghua Hospital, 1000 DongguanAvenue, Guangdong, People’s Republic of China[20]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong, People’s Republic of China中山大学附属第六医院
Purpose To determine the effect of transanal total mesorectal excision (taTME) procedure on the postoperative bowel evacuation function of patients with low rectal cancer. Methods Bowel evacuation function was investigated in 316 patients with rectal cancer after taTME in 18 hospitals in China. Low anterior resection syndrome (LARS) score, Wexner score, and EORTC QLQ-C30 were used for functional evaluation. The association between perioperative risk factors and LARS score was determined by univariate and multivariate analyses. Results The prevalence rate of no LARS, minor LARS, and major LARS in patients after taTME was 39.9%, 28.2%, and 31.9%, respectively. The two most frequently reported symptoms of LARS after taTME were bowel clustering (72.8%) and fecal urgency (63.3%). Patients with major LARS had significantly higher Wexner score and worse global health status and financial difficulties according to the EORTC QLQ-C30 questionnaire than those without major LARS. Preoperative chemoradiotherapy was an independent risk factor of major LARS occurrence after taTME (OR: 3.503, P = 0.044); existing preoperative constipation (OR: 0.082, P = 0.040) and manual anastomosis (OR: 4.536, P = 0.021) were favorable factors affecting bowel evacuatory function within 12 months after taTME, but for patients whose follow-up time was longer than 12 months, postoperative chemoradiotherapy (OR: 8.790, P = 0.001) and defunctioning stoma (OR: 3.962, P = 0.010) were independent risk factors. Conclusions The bowel evacuation function after taTME is acceptable. Perioperative chemoradiotherapy, anastomotic method, and preoperative constipation are factors associated with bowel dysfunction after taTME.
第一作者机构：[1]Department of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, People’s Republic of China[2]Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, People’s Republic of China[2]Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, People’s Republic of China
推荐引用方式(GB/T 7714)：
Shen Zhanlong,Yu Gang,Ren Mingyang,et al.Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer[J].INTERNATIONAL JOURNAL OF COLORECTAL DISEASE.2021,36(4):725-734.doi:10.1007/s00384-020-03824-3.
APA：
Shen, Zhanlong,Yu, Gang,Ren, Mingyang,Ding, Chao,Zhang, Hongyu...&Ye, Yingjiang.(2021).Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,36,(4)
MLA：
Shen, Zhanlong,et al."Multicenter investigation of bowel evacuation function after transanal total mesorectal excision for mid-low rectal cancer".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 36..4(2021):725-734
