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Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis

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Pubmed体系：

收录情况： ◇ 自然指数

作者：
Ziyue Zhou[1,2,3] * ; Xiaoxiang Zhou[4] * ; Xu Jiang[3,5] * ; Bo Yang[6] * ; Xin Lu[6] ; Yunyun Fei[1,2,3] ; Lidan Zhao[1,2,3] ; Hua Chen[1,2,3] ; Li Zhang[7] ; Xiaoyan Si[7] ; Naixin Liang[8] ; Yadong Wang[8] ; Dan Yang[1,2,3] ; Yezi Peng[1,2,3] ; Yiying Yang[1,2,3] ; Zhuoran Yao[9] ; Yangzhige He[3,5] ; Xunyao Wu [3] ; Wen Zhang[1,2,3] ; Min Wang[10] ; Huaxia Yang[1,2,3] ; Xuan Zhang[10] ;
机构： [1]Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [2]Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [3]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [4]Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021 Beijing, China. [5]National Infrastructure for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [6]Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [7]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [8]Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, China. [9]Department of Thoracic Oncology, Cancer Center, and Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, 610041 Chengdu, China. [10]Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Clinical Immunology Center, Chinese Academy of Medical Sciences, 100730 Beijing, China.
出处：
DOI： 10.1038/s41467-024-46195-x

摘要：
Inflammatory arthritis (IA) is a common rheumatic adverse event following immune checkpoint inhibitors treatment. The clinical disparities between IA and rheumatoid arthritis (RA) imply disease heterogeneity and distinct mechanisms, which remain elusive. Here, we profile CD45+ cells from the peripheral blood or synovial fluid (SF) of patients with PD-1-induced IA (PD-1-IA) or RA using single-cell RNA sequencing. We report the predominant expansion of IL1Bhi myeloid cells with enhanced NLRP3 inflammasome activity, in both the SF and peripheral blood of PD-1-IA, but not RA. IL1Bhi macrophages in the SF of PD-1-IA shared similar inflammatory signatures and might originate from peripheral IL1Bhi monocytes. Exhausted CD8+ T cells (Texs) significantly accumulated in the SF of patients with PD-1-IA. IL1Bhi myeloid cells communicated with CD8+ Texs possibly via the CCR1-CCL5/CCL3 and CXCL10-CXCR3 axes. Collectively, these results demonstrate different cellular and molecular pathways in PD-1-IA and RA and highlight IL1Bhi macrophages as a possible therapeutic target in PD-1-IA.© 2024. The Author(s).

基金：
National Key R&D Program of China (2022YFC3602000, X.Z.), the Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-C&TB-041, H.Y., 2021-I2M-1-016, H.Y., 2021-I2M-1-017, X.Z., 2020-I2M-C&T-B011, H.Y., 2021-I2M-1-047, M.W.), National High-Level Hospital Clinical Research Funding (2022-PUMCH-A-106, H.Y., BJ-2022-116, X.Z., BJ-2023- 084, M.W.), Chinese Society of Clinical Oncology (CSCO)‐Pilot Oncology Research Fund (Y-2019AZMS-0452, H.Y.), National Natural Science Foundation of China (82230060, X.Z., 81788101, X.Z., 32141004 X.Z, 82203021 X.Z., 82171799, X.J.), and Peking Union Medical College Hospital Research funding for Postdoc (kyfyjj202317, Z.Z.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [2]Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [3]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology and Clinical Immunology, National Clinical Research Center for Dermatologic and Immunologic Diseases, the Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [2]Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China. [3]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China.
推荐引用方式(GB/T 7714)：
Ziyue Zhou,Xiaoxiang Zhou,Xu Jiang,et al.Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis[J].Nature Communications.2024,15(1):2107.doi:10.1038/s41467-024-46195-x.
APA：
Ziyue Zhou,Xiaoxiang Zhou,Xu Jiang,Bo Yang,Xin Lu...&Xuan Zhang.(2024).Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis.Nature Communications,15,(1)
MLA：
Ziyue Zhou,et al."Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis".Nature Communications 15..1(2024):2107

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