机构：[1]Department of Pathology, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China.四川省肿瘤医院
The incidence of oesophagogastric junction adenocarcinoma has increased rapidly but remains controversial over the last decades. There are two crucial updates of the fifth World Health Organization (WHO) classification, including the alteration of its definition and the emphasis on the human epidermal growth factor receptor 2 (HER2) test.
A total of 566 clinicopathological samples from patients who were diagnosed with gastric adenocarcinoma were retrospectively analyzed. We comprehensively compared the clinicopathological features of oesophagogastric junction adenocarcinoma between the fourth (V4.0) and fifth (V5.0) WHO versions. The clinicalpathological features among oesophagogastric junction, proximal and distal gastric tumors with fourth and fifth edition were also compared, respectively. Also, we discuss the correlation of HER2-expression with clinicopathological features according to the V5.0.
The results showed that the difference was mainly between oesophagogastric junction and distal adenocarcinoma in V4.0, while some were found between proximal and distal adenocarcinoma in V5.0. Tumors invading the oesophagus more than 3cm were still mainly oesophagogastric junction tumors. The expression of HER2 in oesophagogastric junction and proximal gastric adenocarcinoma was still higher than that in gastric body and distal sites.
The clinicopathological parameters of the oesophagogastric junction tumors changed to some extent in the updated WHO version. The proximal gastric tumors tended to be more invasive, more than those located in oesophagogastric junction. But the latter with oesophageal invasion required additional management. The HER2-expression of oesophagogastric junction adenocarcinoma is the highest. The classification of V5.0 is reasonable and worth recommendation.
基金：
Foundation of Health Department of Sichuan
Province (No.120044).
第一作者机构：[1]Department of Pathology, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China.
通讯作者：
通讯机构：[1]Department of Pathology, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China.[*1]Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No.55, section 4, Renmin South Road, 610041, Chengdu, China
推荐引用方式(GB/T 7714)：
Li Yunzhu,Li Jiayu,Li Jiman.Two updates on oesophagogastric junction adenocarcinoma from the fifth WHO classification: Alteration of definition and emphasis on HER2 test.[J].HISTOLOGY AND HISTOPATHOLOGY.2021,36(3):339-346.doi:10.14670/HH-18-296.
APA：
Li Yunzhu,Li Jiayu&Li Jiman.(2021).Two updates on oesophagogastric junction adenocarcinoma from the fifth WHO classification: Alteration of definition and emphasis on HER2 test..HISTOLOGY AND HISTOPATHOLOGY,36,(3)
MLA：
Li Yunzhu,et al."Two updates on oesophagogastric junction adenocarcinoma from the fifth WHO classification: Alteration of definition and emphasis on HER2 test.".HISTOLOGY AND HISTOPATHOLOGY 36..3(2021):339-346
