机构：[1]Key Laboratory of Emergency and Trauma of Ministry of Education & Tumor Institute, the First Affiliated Hospital, Hainan Medical University, Haikou, China[2]Department of Neurology, the First Affiliated Hospital, Hainan Medical University, Haikou, China[3]School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China[4]Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Haikou, China[5]State Key Laboratory of Biotherapy and Cancer Center, West China School of Basic Medical Sciences & Forensic Medicine, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院
Pancreatic cancer (PC) is one of the most common human malignancies worldwide and remains a major clinical challenge. Here, we found that Benproperine phosphate (BPP), a cough suppressant, showed significant anti-cancer effect on PC both in vitro and in vivo via induction of autophagy-mediated cell death. Mechanistical studies revealed that BPP triggered AMPK/mTOR-mediated autophagy initiation and disturbed RAB11A-mediated autophagosome-lysosome fusion, resulting in excessive accumulation of autophagosomes. Inhibition of autophagy or overexpression of RAB11A partially reversed BPP-induced growth inhibition in PC cells, suggesting that BPP might induce lethal autophagy arrest in PC cells. Together, our study identifies BPP as a potent anti-tumor agent for PC by inducing autophagy arrest, providing a new potential therapeutic strategy for the treatment of PC.
This article is protected by copyright. All rights reserved.
基金：
This work was supported by grants from the National
Natural Science Foundation (81960528 and 81760553
to SJZ), the Finance Science and Technology Projects
of Hainan Province (2017CXTD008 to SJZ,
ZDYF2018157 to LM, 818QN245 to XDZ, and
ZDYF2019148 to YDL), and Guangdong Basic and
Applied Basic Research Foundation (2019B030302
012).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2025]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Key Laboratory of Emergency and Trauma of Ministry of Education & Tumor Institute, the First Affiliated Hospital, Hainan Medical University, Haikou, China[2]Department of Neurology, the First Affiliated Hospital, Hainan Medical University, Haikou, China[3]School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China[4]Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Haikou, China
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Emergency and Trauma of Ministry of Education & Tumor Institute, the First Affiliated Hospital, Hainan Medical University, Haikou, China[2]Department of Neurology, the First Affiliated Hospital, Hainan Medical University, Haikou, China[3]School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China[4]Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Haikou, China[*1]The First Affiliated Hospital of Hainan Medical University, Haikou, China[*2]Key Laboratory of Emergency and Trauma of Ministry of Education & Tumor Institute of the First Affiliated Hospital of Hainan Medical University, 3 Xueyuan Road, Longhua District, Haikou, 571199, China
推荐引用方式(GB/T 7714)：
Huanyu Zhang,Zhe Zhang,Yonghao Huang,et al.Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest.[J].Molecular oncology.2021,15(2):725-738.doi:10.1002/1878-0261.12854.
APA：
Huanyu Zhang,Zhe Zhang,Yonghao Huang,Siyuan Qin,Li Zhou...&Qifu Li.(2021).Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest..Molecular oncology,15,(2)
MLA：
Huanyu Zhang,et al."Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest.".Molecular oncology 15..2(2021):725-738
