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Repurposing antitumor drugs for the treatment of non-oncological diseases: Mechanistic insights, clinical evidence, and future perspectives

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机构： [1]Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. [2]Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. [3]Institute of Precision Drug Innovation and Cancer Center, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China. [4]Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China. [5]Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

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关键词： Drug repurposing Antitumor drugs Non-oncological diseases Targeted therapy

摘要：

Repurposing antitumor drugs for non-oncological diseases has emerged as a promising strategy to address unmet medical needs across diverse therapeutic areas. These drugs, originally developed to target cancer-related pathways, have demonstrated potential in treating various conditions by modulating critical biological processes. This review systematically explores innovative approaches to optimize drug repurposing and investigates the therapeutic potential of clinically approved antitumor agents in managing a broad spectrum of diseases, including infectious diseases, otorhinolaryngological and ophthalmic diseases, respiratory and urological diseases, digestive and reproductive system diseases, skin and musculoskeletal diseases, immunological diseases, nervous system diseases, cardiovascular and hematological diseases, among others. By summarizing the mechanisms of action, clinical trials, and challenges associated with repurposing antitumor drugs, this review highlights their broad applicability in treating complex diseases. The insights aim to inspire further research and guide future drug discovery, ultimately advancing translational medicine and expanding therapeutic possibilities.Copyright © 2025 Elsevier Inc. All rights reserved.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学

第一作者：

第一作者机构： [1]Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

通讯作者：

通讯机构： [2]Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. [3]Institute of Precision Drug Innovation and Cancer Center, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.

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